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Chin tightening cream with dimethylaminoethanol to help make a double chin look smaller

Dimethylaminoethanol-based formulation for improvement of appearance of double chin - NIL

Status
Recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091213
Enrollment
30
Registered
2025-07-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Topical dimethylaminoethanol cream for double chim: Participants will apply a topical dimethylaminoethanol (DMAE) cream once daily at night to the clean, dry submental area for 8 weeks.

Sponsors

Silphion Research Private Limited
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18 to 60 years 2. Mild to moderate submental fullness 3. No known allergy to topical products 4. Informed & photographic consent provided 5. Willing to comply with study protocol

Exclusion criteria

Exclusion criteria: 1. Pregnancy or lactation 2. Recent submental treatments (RF, botox, fillers) 3. Skin conditions like eczema or dermatitis in the area 4. Systemic illness or ongoing steroid/immunosuppressant therapy 5. Active acne in the submental area

Design outcomes

Primary

MeasureTime frame
Change in submental skin elasticity by measuring Retraction Time via DermaLab Combo elasticity probeTimepoint: Day 0, Day 7, Day 14, Day 21, Day 28, Day 42, Day 56

Secondary

MeasureTime frame
Visual improvements assessed by standardized photos Timepoint: Day 0, Day 7, Day 14, Day 21, Day 28, Day 42, Day 56

Countries

India

Contacts

Public ContactSavitha Murali

Render Skin and Hair

drsavitha@renderclinic.com6385519654

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026