Skip to content

Comparing Twin Mix and Standard Lignocaine for Pain Relief During Premolar Removal in Patients undergoing orthodontic treatment : A Randomized Trial

Comparative evaluation of effectiveness of Twin mix vs 2 percent Lignocaine HCL with 1:2,00,000 Epinephrine for pain control during removal of orthodontically indicated mandibular premolar: A randomized controlled trial - nil

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091212
Enrollment
60
Registered
2025-07-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G891- Acute pain, not elsewhere classified Health Condition 2: K084- Partial loss of teeth

Interventions

Intervention1: Twin mix: 1.8 ml of 2 percent lignocaine hydrochloride with 1:200000 epinephrine and 1 ml of 4 mg dexamethasone Control Intervention1: Local Anaesthesia: 2 percent Lignocaine HCL wit

Sponsors

Self
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patient requiring bilateral extraction of Mandibular premolar 2) Patients over age of 15-40 years both male and female will be included in this study 3) Systemically healthy patients 4) Co-operative motivated and hygiene conscious patients

Exclusion criteria

Exclusion criteria: 1) Pregnant or lactating females 2) Patient with periapical infection in mandibular premolars 3) Allergy to any local anesthetic agent and anti-inflammatory drugs 4) Patients with high risk systemic diseases 5) Those who deny for consent and follow up

Design outcomes

Primary

MeasureTime frame
Pain during deposition of anaesthesia Onset of anaesthesia Pain during extraction of tooth Duration of anaesthesia Need for post operative analgesia Mouth opening Timepoint: baseline 24 hours

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Hrushikesh Malikar

Ranjeet Deshmukh Dental College and Research Centre

kbang27@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026