Evaluation of salivary proteins expression and dental caries in diabetic and non-diabetic children with and without topical remineralization therapy

To evaluate and compare aquaporin 5 (AQP-5) salivary flow rate and caries experience in children with type 1 diabetes mellitus and non diabetic children before and after topical remineralizing therapy - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091199

Enrollment

Registered

2025-07-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E109- Type 1 diabetes mellitus without complications

Interventions

Intervention1: Nanosilver Fluoride: 5% nanosilver fluoride applied topically on carious teeth Intervention2: Aquaporin 5 and Salivary Flow Rate : Intra-group quantification of aquaporin 5 and salivary

Eligibility

Inclusion criteria

Inclusion criteria: Children with 7 to 12 years of age. Non Diabetic children without dental caries. Non-Diabetic Children with ICDAS II criteria CODE 03 and 04. Children with Type1 Diabetes Mellitus having ICDAS II criteria, CODE 03 and 04. Parents giving consent for the study

Exclusion criteria

Exclusion criteria: Children who received fluoride topical application during the last 1 month. Children requiring special health care needs. Pulpally involved and grossly decayed teeth.

Design outcomes

Primary

Measure	Time frame
Quantification of Aquaporin-5 and Salivary Flow Rate in Non-Diabetic children Without Dental Caries. Quantification of Aquaporin-5 and Salivary Flow Rate in Non-Diabetic children having dental caries, before and after the application of topical remineralizing therapy. Timepoint: Baseline - 1 month	—

Secondary

Measure	Time frame
Quantification of Aquaporin-5, Salivary Flow Rate and dental caries experience in children with Type 1 Diabetes Mellitus before and after the application of topical remineralizing therapy. Comparative Analysis of Aquaporin-5, Salivary Flow Rate, and Caries Experience between Non-diabetic and Type 1 Diabetic Mellitus children before and after the application of topical remineralizing therapy. Timepoint: Baseline - 1 month	—

Measure

Time frame

Quantification of Aquaporin-5, Salivary Flow Rate and dental caries experience in children with Type 1 Diabetes Mellitus before and after the application of topical remineralizing therapy. Comparative Analysis of Aquaporin-5, Salivary Flow Rate, and Caries Experience between Non-diabetic and Type 1 Diabetic Mellitus children before and after the application of topical remineralizing therapy. Timepoint: Baseline - 1 month

—

Countries

India

Contacts

Public ContactDR ABHIRAMI K

Rajarajeswari Dental College and Hospital

jaya.vrushabh@gmail.com9880038038

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026