Effects of vasodilating drugs in patients vitals while getting off from Heart Lung Machine

A comparative study evaluating the effects of propofol and Nitroglycerine infusion on patients hemodynamic while weaning off from cardiopulmonary bypass posted for cardiac surgery - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091175

Enrollment

100

Registered

2025-07-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection Propofol infusion.: Propofol infusion is started while weaning off from Cardio-pulmonary bypass. Control Intervention1: Injection Nitroglycerine Infusion: Injection Nitrogltce

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for Cardiac Surgeries.

Exclusion criteria

Exclusion criteria: 1. Patients not willing to give informed consent 2. Extremes of age 3. Patients posted for CABG 4. Patients with severe systolic LV dysfunction. 5.patients posted for combined cardiac and major vascular surgeries. 6. Cardio-pulmonary Bypass time more than 90 minutes. 7. HbA1c more than 6.5

Design outcomes

Primary

Measure	Time frame
The effect of propofol infusion in achieving vasodilation and controlled hypotension perioperatively as compared to Nitroglycerine infusion.Timepoint: while weaning off from cardio-pulmonary bypass	—

Secondary

Measure	Time frame
1. Comparison of total ionotropic requirement after separation of cardiopulmonary bypass among the two groups. 2. Comparison of hemodynamic fluctuations while shifting the patients from Operating room to ICU among the two groups.Timepoint: while weaning off from cardiopulmonary bypass and while shifting the patient to ICU	—

Countries

India

Contacts

Public ContactKanchan Gupta

King Georges Medical University

drvinitasingh70@gmail.com9415080782

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026