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Unveiling Phosphatase Shifts following Periodontal Therapy in Current Smokers, former Smokers, and Non-Smokers with Chronic Periodontitis

Comparative Evaluation of Periodontal therapy on Salivary Alkaline Phosphatase and Acid Phosphatase level in Non-smoker and Smoker with Chronic Periodontitis:A Biochemical Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091129
Enrollment
60
Registered
2025-07-18
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Non-surgical periodontal therapy ALP and ACP reagent: At Day 1 a written consent form was obtained from each patient. Initial clinical examination, including bleeding on probing (BOP),

Sponsors

DrSupriti dutta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects unable to provide informed consent or comply with study protocol. 2. Patients with oral potentially malignant disorders and systemic illnesses such as diabetes, hypertension, thyroid or any known endocrine disorders, osteoarthritis, osteosarcoma, and renal failure were excluded. 3. Subjects with presence of fixed prosthesis and orthodontics appliances. 4. Patients presented with systemic disease, pregnant female, lactating or postmenopausal female.

Exclusion criteria

Exclusion criteria: 1. Subjects unable to provide informed consent or comply with study protocol. 2. Patients with oral potentially malignant disorders and systemic illnesses such as diabetes, hypertension, thyroid or any known endocrine disorders, osteoarthritis, osteosarcoma, and renal failure were excluded. 3. Subjects with presence of fixed prosthesis and orthodontics appliances. 4. Patients presented with systemic disease, pregnant female, lactating or postmenopausal female.

Design outcomes

Primary

MeasureTime frame
The primary outcomes were changes in alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in saliva following periodontal therapy along with gingival index,plaque index,clinical attachment level and probing depth and comparing before and after result.Timepoint: The primary outcomes were changes in alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in saliva following periodontal therapy at baseline,15th day and 4week along with gingival index,plaque index,clinical attachment level and probing depth at baseline and 4weeks and comparing before and after result.

Secondary

MeasureTime frame
Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), & gingival index (GI) were assessed at baseline & at 4week post-treatment to evaluate the clinical effectiveness of periodontal therapy in current smoker,former smoker & non-smoker groups.Timepoint: Clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI) were recorded at baseline (Day 0) & at 4 weeks post-treatment, corresponding with the biochemical follow-up at baseline,15th day & 4week.

Countries

India

Contacts

Public ContactDr Supriti Dutta

Nims Dental College and hospital,Jaipur

a82874187@gmail.com08602725028

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026