Health Condition 1: M170- Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention1: Physiotherapy+NSAID: Physiotherapy protocol including supervised quadriceps strengthening and knee mobilization exercises, along with oral NSAID (Group P (n=55) will receive Aceclofenac
Sponsors
Dr Priyanka S
Dr Charumathi P C
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subjects of either gender aged between 40 and 70 years with symptomatic idiopathic osteoarthritis (OA) of bilateral knee joint involvement for a minimum period of 3 months. 2. Subjects with radiological evidence of (Kellgren-Lawrence)KL-Grade-1,2 OA of knee joint. 3. Subjects with morning stiffness less than 30 minutes duration with crepitus on motion. 4. Subjects who have the ability to perform physical therapy exercise. 5. Subjects willing to sign the informed consent and comply with study procedure.
Exclusion criteria
Exclusion criteria: 1. Subjects with history of surgery or acute trauma to the knee joint within 6 months. 2. Subjects with history of underlying inflammatory arthropathy or severe rheumatoid arthritis or severe osteoarthritis. 3. Subjects having known allergy to NSAIDS. 4. Subjects with diseases and surgeries related to lower limb and spine. 5. Female subjects who are pregnant, breast feeding or planning to become pregnant 6. Subjects with history of neurological, cardiovascular disorders, peptic ulcers, GI bleeding, Psychiatric illness, Bronchial asthma, acute inflammatory arthritis, pseudogout, deranged hepatic or renal system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in visual analogue scale (VAS) pain score from baseline to day 7, day 14, day 21 2. Change in WOMAC total score from baseline to day 7, 14 and 21 3. Change in WOMAC sub score: pain, stiffness, physical function from baseline to day 7, day 14, day 21.Timepoint: 1. Change in visual analogue scale (VAS) pain score from baseline to day 7, day 14, day 21 2. Change in WOMAC total score from baseline to day 7, 14 and 21 3. Change in WOMAC sub score: pain, stiffness, physical function from baseline to day 7, day 14, day 21. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Global assessment of response to therapy (GART) at the end of day 21Timepoint: Day 21 | — |
Countries
India
Contacts
Public ContactDr Charumathi P C
KEMPEGOWDA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed