Comparison of two drugs Clonidine and Nalbuphine added to Ropivacaine in spinal anesthesia for better pain relief during surgeries

Comparative evaluation of intrathecal clonidine and nalbuphine as an adjuvant to hyperbaric ropivacaine in subarachnoid block - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091103

Enrollment

Registered

2025-07-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intrathecal Clonidine and Nalbuphine with Hyperbaric Ropivacaine : Group RC (Clonidine group): Injection hyperbaric ropivacaine 0.75%, 3.7 ml + clonidine 30 g (0.2 ml) Group RN (Nalbup

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for surgery under subarachnoid block ASA physical status I and II Patients who give informed consent

Exclusion criteria

Exclusion criteria: Morbid obesity Patient with history of adverse response to study drugs Patient with pre-existing neurological or spinal disease, cardiovascular disease, renal, hepatic or any other systemic disease Contraindications for spinal anaesthesia like: Raised ICP, local site infections & spinal deformities like kyphosis and scoliosis Pregnant females Coagulopathy or bleeding diathesis

Design outcomes

Primary

Measure	Time frame
Time of onset of sensory and motor blockade (assessed using pinprick method and Modified Bromage scale respectively)Timepoint: Time of onset of sensory and motor blockade upto 24 hours postoperatively (assessed using pinprick method and Modified Bromage scale respectively)	—

Secondary

Measure	Time frame
To compare the duration of sensory and motor blockade assessed by pin prick, Visual Analog Score (VAS) and modified Bromage scale respectively. Changes in vitals parameters-heart rate (HR), noninvasive blood pressure (NIBP), and oxygen saturation (SPO2) intra operatively. Requirement of first rescue analgesic in postoperative period in the first 24 hours.Timepoint: Assessed every 1 min until onset, then every 10 min post 2 hours until full recovery Baseline, then every 5 minutes intraoperatively and every 15 minutes post-op for 3 hours Monitored continuously up to 24 hours post-op	—

Measure

Time frame

To compare the duration of sensory and motor blockade assessed by pin prick, Visual Analog Score (VAS) and modified Bromage scale respectively. Changes in vitals parameters-heart rate (HR), noninvasive blood pressure (NIBP), and oxygen saturation (SPO2) intra operatively. Requirement of first rescue analgesic in postoperative period in the first 24 hours.Timepoint: Assessed every 1 min until onset, then every 10 min post 2 hours until full recovery Baseline, then every 5 minutes intraoperatively and every 15 minutes post-op for 3 hours Monitored continuously up to 24 hours post-op

—

Countries

India

Contacts

Public ContactDr Anubhuti Singh

School of Medical Sciences and Research Sharda University

manish.agarwal@sharda.ac.in9838706199

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026