Health Condition 1: N181- Chronic kidney disease, stage 1 Health Condition 2: N182- Chronic kidney disease, stage 2 (mild) Health Condition 3: N183- Chronic kidney disease, stage 3 (moderate)
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Dr. Mohammad Rafi Shaik
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years or older as of the index date. 2. Patients belonging to all genders. 3. Patients with a diagnosis of chronic kidney disease stages G1, G2, G3A, G3B and A1, and A2 as per KDIGO guidelines, on or up to 12 months before the index date. 4. Patient with serum Potassium less than or equal to 5.2 mEq/L.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing haemodialysis or peritoneal dialysis. 2. Patients who are already on SGLT-2 inhibitors and NSMRA before the index date. 3. Patients treated with new immunosuppressant therapy for new or relapse kidney disease within the last 2 months 4. Patients with known hypersensitivity to SGLT2 inhibitors or NSMRAs 5. Current pregnancy or lactation 6. Known cases of type 1 diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To compare the effects of the combination therapy of Non-Steroidal Mineralocorticoid Receptor Antagonists and Sodium Glucose Cotransporter-2 inhibitors in terms of reducing the fall in eGFR (estimated glomerular filtration rate), UPCR (Urine protein to creatinine ratio), and Serum Creatinine to that of Sodium Glucose Cotransporter-2 inhibitor therapy alone, along with the standard care. 2. To evaluate the effects of Sodium Glucose Cotransporter-2 inhibitor alone and in combination with finerenone on Serum Potassium levels Timepoint: Every 3 months for 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the quality of life and compare the same among the two treatment groups. 2. To compare the frequency of adverse events between the two treatment groups Timepoint: Every 3 months for 1 year | — |
Countries
India
Contacts
Public ContactDr Mohammad Rafi Shaik
Kasturba Medical College, Mangalore
Outcome results
None listed