Comparing Ozonated Olive Oil Plus Steroids vs Steroids alone in treating Symptomatic Oral Lichen Planus A Randomized Controlled Trial

Evaluating the Efficacy Of Ozonated Olive Oil & Topical Steroids With Topical Steroid Therapy alone in patients with symptomatic OLP A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091040

Enrollment

Registered

2025-07-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L00-L08- Infections of the skin and subcutaneous tissue

Interventions

Intervention1: Ozonated Olive oil: Ozonated Olive oil is a natural product created by bubbling ozone gas through high quality , cold pressed olive oil for an extended period . This process saturates

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients of either gender and age 18 - 60 yrs 2) Patients with clinical diagnosed symptomatic oral lichen planus 3) Patients willing to participate in the study and for follow up

Exclusion criteria

Exclusion criteria: 1)Patients having systemic disorders such as hyperthyroidism, severe anaemia and G6PD Deficiency are excluded 2)Patients who are undergoing any other treatment for oral lichen planus. 3)Patients who showed dysplasia on velscope examination 4)Patients who are not co operative with the application of topical steroid therapy and ozonated olive oil according to the instructions given will be excluded from the study

Design outcomes

Primary

Measure	Time frame
The primary outcome for application of ozonated olive oil results in reduction in burning sensation and pain reduction on lesion size and severity anti inflammatory effect no systemic side effects improved patient compliance resulting in non stinging , soothing nature that promotes adherence Unlike corticosteroids ozone does not suppress immunityTimepoint: Patients will be evaluated on the 7th 14th 21st 28th day and will be followed up for 2 to 4 months	—

Measure

Time frame

The primary outcome for application of ozonated olive oil results in reduction in burning sensation and pain reduction on lesion size and severity anti inflammatory effect no systemic side effects improved patient compliance resulting in non stinging , soothing nature that promotes adherence Unlike corticosteroids ozone does not suppress immunityTimepoint: Patients will be evaluated on the 7th 14th 21st 28th day and will be followed up for 2 to 4 months

—

Secondary

Measure	Time frame
To evaluate the effect of ozonated olive oil on the subjective symptoms of oral lichen planus , including pain relief, burning sensation and patient reported quality of life as well as to monitor for any adverse reactions , recurrence rate and tolerability of the treatment over the study periodTimepoint: The patient will be evaluated on the 7th,14th,21st,28th,2months and 6 months during the course of the study	—

Measure

Time frame

To evaluate the effect of ozonated olive oil on the subjective symptoms of oral lichen planus , including pain relief, burning sensation and patient reported quality of life as well as to monitor for any adverse reactions , recurrence rate and tolerability of the treatment over the study periodTimepoint: The patient will be evaluated on the 7th,14th,21st,28th,2months and 6 months during the course of the study

—

Countries

India

Contacts

Public ContactDr Vedika Pillai

vedikapillai14@gmail.com9167742065

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026