A study comparing dexmedetomidine and remifentanil on blood pressure and recovery in patients undergoing endoscopic sinus surgery (FESS).

A comparative study of the effects of dexmedetomidine and remifentanil on perioperative hemodynamics and recovery profile in patients undergoing functional endoscopic sinus surgery - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090988

Enrollment

Registered

2025-07-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A: Dexmedetomidine (DEM) : Dose: 1 g/kg IV loading over 10 minutes before induction, followed by 0.5 g/kg/hr infusion Route: Intravenous Frequency: Single loading dose followed

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective Functional Endoscopic Sinus Surgery (FESS). Gender: Male and female participants. Age Range: 18 to 60 years. Body Mass Index (BMI): Less than 30 kilograms per square meter (kg/m ). ASA Physical Status Classification: Grade I and II according to the American Society of Anesthesiologists (ASA) guidelines.

Exclusion criteria

Exclusion criteria: Patients who are not willing to participate Patients under ASA 3 and ASA 4 Hemodynamic instability defined as intraoperative uncontrolled blood pressure more than 180 by 100 mmHg or less than 90 by 50 mmHg despite appropriate management BMI greater than or equal to 30 kg per m2 Pregnant or lactating patients Patients with conditions impairing effective communication and assessment

Design outcomes

Primary

Measure	Time frame
To compare perioperative hemodynamic alterations, including pressure, -heart rate, - oxygen saturation(spo2) 2)To evaluate postoperative recovery using the Modified Aldrete Score.Timepoint: To compare perioperative hemodynamic alterations, including pressure, -heart rate, - oxygen saturation(spo2) 2)To evaluate postoperative recovery using the Modified Aldrete Score.	—

Secondary

Measure	Time frame
Postoperative Pain Measured using the Visual Analog Scale (VAS) Sedation Levels Measured using the Richmond Agitation Sedation Scale (RASS) Intraoperative Bleeding Measured by estimating the amount of blood loss or by surgeon assessment Surgeon Satisfaction Measured using the Likert ScaleTimepoint: Postoperative Pain (VAS) Immediately postoperatively in PACU 30 minutes postoperatively 1 hour postoperatively 2 hours postoperatively 4 hours postoperatively 6 hours postoperatively Sedation Levels (RASS) Preoperative baseline Every 15 minutes intraoperatively 15, 30, 45, and 60 minutes postoperatively Intraoperative Bleeding During the surgery (measured continuously or at defined intervals during the procedure) Surgeon Satisfaction (Likert Scale) Immediately after surgery (at the end of the procedure)	—

Measure

Time frame

Postoperative Pain Measured using the Visual Analog Scale (VAS) Sedation Levels Measured using the Richmond Agitation Sedation Scale (RASS) Intraoperative Bleeding Measured by estimating the amount of blood loss or by surgeon assessment Surgeon Satisfaction Measured using the Likert ScaleTimepoint: Postoperative Pain (VAS) Immediately postoperatively in PACU 30 minutes postoperatively 1 hour postoperatively 2 hours postoperatively 4 hours postoperatively 6 hours postoperatively Sedation Levels (RASS) Preoperative baseline Every 15 minutes intraoperatively 15, 30, 45, and 60 minutes postoperatively Intraoperative Bleeding During the surgery (measured continuously or at defined intervals during the procedure) Surgeon Satisfaction (Likert Scale) Immediately after surgery (at the end of the procedure)

—

Countries

India

Contacts

Public ContactDr Prerna Biswal

IMS and SUM Hospital

prerna.biswal@gmail.com9078671478

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026