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How Different Ways of Handling the Umbilical Cord at Birth Affect Blood Flow in Premature Babies

Effect of immediate cord clamping, intact cord milking, and cut cord milking on hemodynamics in non-vigorous preterm neonates born at 28+0 to 33+6 Weeks Gestation: A Randomized Controlled Trial (CORDIAL)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/090984
Enrollment
141
Registered
2025-07-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P073- Preterm [premature] newborn [other]

Interventions

Intervention1: intact umbilical cord milking: Non vigorous neonates born between 28+0 to 33+6 weeks will receive intact umbilical cord milking. Intervention2: cut umbilical cord milking: Non vigorous

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Non vigorous (not breathing or crying at birth) neonates born between 28+0 to 33+6 weeks gestation age.

Exclusion criteria

Exclusion criteria: Antenatally detected major malformations, hydrops fetalis, suspected chromosomal anomalies, Rh negative pregnancies with positive ICT, Monochorionic twins, cord prolapse, antepartum hemorrhage.

Design outcomes

Primary

MeasureTime frame
Superior vena cava flowTimepoint: 12 2 hours—

Secondary

MeasureTime frame
Saturation and heart rateTimepoint: 5 mins;temperatureTimepoint: 10 mins;hematocritTimepoint: 4( 2) hrs;Mean blood pressure, perfusion index and need for inotropic supportTimepoint: 24( 2) hours;Intraventricular hemorrhage (IVH), mortalityTimepoint: 28 days;Hematocrit and ferritin levelsTimepoint: 6 weeks—

Countries

India

Contacts

Public ContactDr Usha Devi R

Jawaharlal Institute of Postgraduate Medical Education and Research

drushaa@gmail.com9962653294

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026