A clinical trial to study the comparison of two drugs with ultrasonic nebulisation for attenuating intubation response to laryngoscopy.

Evaluation of dexmedetomidine nebulisation versus four percentage lignocaine nebulisation for attenuation of intubation response to laryngoscopy & endotracheal tube intubation: Prospective randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090969

Enrollment

Registered

2025-07-15

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N200- Calculus of kidney Health Condition 2: S669- Injury of unspecified muscle, fascia and tendon at wrist and hand level Health Condition 3: G55- Nerve root and plexus compressionsin diseases classified elsewhere Health Condition 4: E078- Other specified disorders of thyroid

Interventions

Intervention1: Ultrasonic nebulization with dexmedetomidine: Before 30 minutes of intubation patient is nebulized with dexmedetomidine (1mcg/kg) and calculate the sedation score and note the vitals of

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients requiring general anesthesia and tracheal intubation. 2. ASA grade I and II patients. 3. Duration of surgery less than 4 hours.

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Emergency surgeries 3. Hemodynamically unstable patients 4. Pregnancy 5.Previous allergy to anesthetic agents

Design outcomes

Primary

Measure	Time frame
To compare the efficacy & safety of nebulized dexmedetomidine, nebulized 4% lignocaine for blunting of pressor effect caused by laryngoscopy and endotracheal intubation.Timepoint: At baseline, 1 minute, 2 minutes, 3 minutes, 5 minutes, 7 minutes , 10 minutes, after intubation	—

Secondary

Measure	Time frame
To evaluate the post-operative complications occurring after intubation and laryngoscopy like sore throat, difficulty in swallowing, speech problems and side effects of anesthetic agents.Timepoint: postoperative period within 24 hours	—

Countries

India

Contacts

Public ContactDr Srilata Moningi

Nizams Institute of medical sciences

srilata_m1973@yahoo.co.in9848352882

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026