Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Ropivacaine: 0.25% ropivacaine through epidural catheter, 5 ml bolus before incision followed by 5 ml/hr infusion. duration- from surgical incision time to skin closure time
Control Int
Sponsors
K V Aadhira
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients who have given written and valid consent to participate in study, 2) Age more than 18 years, 3) Patients of either sex, 4) Patients with normal liver function - no jaundice no raised enzymes in lab values and coagulation profile (prothrombin time, activated partial thromboplastin time and INR as per lab values) 5) BMI less than 35 kg per m2, 6) ASA grade of patient 3 or 4 where grade 3 is a patient with severe Systemic disease and grade 4 is a patient with severe Systemic disease that is a constant threat to life.
Exclusion criteria
Exclusion criteria: 1) Patient refusal, 2) Patients with history of allergy to local anesthetic, 3) Patients undergoing native kidney nephrectomy along with renal transplant 4) CKD patients with cardiomyopathy- hypertrophic or dilated and Heart failure- as defined by Ejection fraction less than 45% and severe breathless at rest and orthopnea 5)Hemodynamically unstable patients with severe hypotension that is baseline BP of less than 90/60 mmHg before surgery, 6) Pregnant patients, 7) Patients with absolute contraindication to epidural catheterization- local site infection in the lumbar region, coagulopathy or bleeding diathesis and severe hypovolemia. 8) Cold Ischemia time more than 16 hours, that is the time from cold perfusate injection after retrieval to reperfusion with recipient blood
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the effect of epidural ropivacaine on Intravenous fluid given intraoperatively as compared with epidural injection of fentanyl.Timepoint: From Induction of anesthesia to after extubation of patient in kidney transplant recipients. Total IV fluid given will be calculated and noted. | — |
Secondary
| Measure | Time frame |
|---|---|
| to evaluate the need for vasopressor requirement to maintain haemodynamic targets when administering epidural ropivacaine as compared to epidural fentanyl during renal transplant surgeryTimepoint: From Induction of anesthesia to the extubation of patient after kidney transplant surgery, the need for vasopressor requirement will be noted. | — |
Countries
India
Contacts
Public ContactKakumanu Venkata Aadhira
Nizams Institute of Medical Sciences
Outcome results
None listed