Health Condition 1: J441- Chronic obstructive pulmonary disease with (acute) exacerbation
Conditions
Interventions
Intervention1: High flow nasal cannula: High flow nasal cannula therapy to treat acute exacerbation of COPD with type 2 respiratory failure
Control Intervention1: Non- invasive ventilation: Non-invasi
Sponsors
SDM medical college and hospital
Eligibility
Inclusion criteria
Inclusion criteria: Adults diagnosed with COPD exacerbation according to GOLD criteria. Arterial pH between 7.25 to 7.35 at time of presentation (mild to moderate exacerbation) Arterial PaCO2 more than 45mmHg at time of presentation.
Exclusion criteria
Exclusion criteria: Patient who are on long term domiciliary NIV therapy. Clinical cardiovascular instability. Acute failure of more than equal to two organs. Need for immediate intubation or cardiorespiratory arrest. Facial / neck trauma or deformity Consent withdrawal. Treatment refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate whether HFNC therapy is non-inferior to NIV in reducing arterial pCO2 and pH after 12 and 24 hours of treatment in patients with acute exacerbation of COPD.Timepoint: At the end of 12 hours and 24 hours from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the change in respiratory rate, dyspnea score using Modified Borg scale, and treatment change rates at 12 and 24 hours of treatment.Timepoint: At the end of 12 hours and 24 hours from baseline. | — |
Countries
India
Contacts
Public ContactDr Aditya Bhargav K
SDM college of medical sciences and hospital
Outcome results
None listed