Health Condition 1: K80- Cholelithiasis
Conditions
Interventions
Intervention1: Anesthesia with opioids: Anaesthesia to be induced in all the patients with propofol 1 to 2 mg/kg, fentanyl 1- 2 microgms/kg and atracurium 0.5mg/kg
Multimodal analgesia regimen to be u
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age above 60 years. 2. Either sex 3. Undergoing laparoscopic cholecystectomy over 60 minutes 4. ASA I-II 5. Can give informed consent themselves 6. Minimum cognitive performance required to participate is ACE-III score more than 88
Exclusion criteria
Exclusion criteria: EXCLUSION CRITERIA: 1. Patients with a history suggestive of dementia (either listed in the medical record or reported by the patient) or any neurological disorder. 2. History of alcohol abuse, chronic opioid or other substance abuse 3. History of cerebral surgeries, stroke. 4. History suggestive of psychiatric disease like schizophrenia, dementia, anxiety or other disorder affecting cognition, mental dysfunction 5. Prescription of central nervous system active medications (eg: antidepressants, antipsychotics, sedatives)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the association between opioids and frontal lobe hypoperfusion indicated by using NIRS.Timepoint: Baseline, every 10 minutes intraoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the incidence of post operative delirium 3. To determine the association between cerebral perfusion & incidence of postoperative cognitive dysfunction & delirium Timepoint: Baseline 24 hours post surgery 48 hours post surgery 30 days post surgery | — |
Countries
India
Contacts
Public ContactPuneet Khanna
All India INSTITUTE of Medical Sciences New Delhi
Outcome results
None listed