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A Study of the Effect of Intratracheal and Intravenous Lignocaine on Airway and Hemodynamic responses during Emergence and Extubation in Laparoscopic Cholecystectomy under General Anesthesia.

A Randomized Controlled Study of the Effect of Intratracheal and Intravenous Lignocaine on Airway and Hemodynamic responses in comparison with placebo Control during Emergence and Extubation in Laparoscopic Cholecystectomy under General Anesthesia at SMS Medical College, Jaipur - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/090895
Enrollment
156
Registered
2025-07-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K80- Cholelithiasis

Interventions

Intervention1: Intratracheal Lignocaine: 5 minutes before extubation , Intratracheal administration of 2% lignocaine at 3mg/kg dose. Intervention2: Intravenous Lignocaine: 3 minutes before extubation,

Sponsors

SMS Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing laparoscopic cholecystectomy under general anaesthesia. 2.Patients giving written and informed consent. 3.Patients age group between 18-70 years. 4.Patients with an American Society of Anaesthesiologist (ASA)class1,2&3.

Exclusion criteria

Exclusion criteria: 1.Patients with previous history of anaphylaxis/known allergy to lignocaine. 2.Patients with high risk of aspiration. 3.Patients with anticipated difficult airway. 4.Patients with history of chronic cough or bronchial asthma. 5.Patients with history of hypertension on beta blockers. 6.Patients with history of tracheal or laryngeal surgery. 7.Patient already a part of any other study.

Design outcomes

Primary

MeasureTime frame
1.Proportion of cases of each cough reflex grade. 2.Mean of Heart rate , Systolic blood pressure, Diastolic blood pressure.Timepoint: Monitoring parameters at baseline , extubation, 1,2,3 and 5 minutes before and after extubation.—

Secondary

MeasureTime frame
1.Mean emergence time 2.Proportion of cases with adverse eventsTimepoint: Assessed at 5 minutes post extubation—

Countries

India

Contacts

Public ContactDr Prajwal H L

SMS Medical College

anupamag213@gmail.com9414240245

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026