Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Oral Clonidine: Oral Clonidine 0.1 mg given 90 min prior to surgery dissolved in 10 millilitres water To attenuate hemodynamic responses (heart rate and blood pressure changes) during l
Sponsors
Mahatma Gandhi Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patient posted for elective surgery under General anesthesia Patient aged between 18-65 years Patient with American Society of anesthesiologists (ASA) Class I, II Consented Patients
Exclusion criteria
Exclusion criteria: Anticipated difficult intubation Pregnant and lactating females Patient receiving treatment with either of the study drug or having known case of allergy to either drugs or any drugs Patients with prolonged laryngoscopy time(more than 30 seconds) Body Mass Index (BMI) more than 30 kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to compare different effect of oral melatonin versus oral clonidine as premedication and its response changes in blood pressure , heart rate, and other relevant haemodynamic parameters during direct laryngoscopy and tracheal intubation during induction of general anesthesia in elective surgeryTimepoint: Baseline vitals followed by vitals at 5,10,15,30,60,90 minutes pre induction vitals followed by vitals at laryngoscopy followed by vitals at 5,10,15,30 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| to evaluate any differences in side effects or adverse effects between two study groupsTimepoint: Baseline vitals and sedation score followed by vitals and sedation score at 5,10,15,30,60,90 minutes pre induction vitals followed by vitals at 5,10,15,30 minutes and postoperative vitals and sedationscoreat5,10,15,30,60 minutes. | — |
Countries
India
Contacts
Public ContactKhayyam Moin
Mahatma Gandhi Medical College and Hospital
Outcome results
None listed