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Effect of scaling on ghrelin and Tumor necrosis factor -alpha molecules levels in gingival crevicular fluid of healthy individuals and chronic generalised periodontitis with and without Type 2 diabetes mellitus

EFFECT OF NON SURGICAL PERIODONTAL THERAPY ON GHRELIN AND TUMOR NECROSIS FACTOR -ALPHA (TNF-a) IN GINGIVAL CERVICULAR FLUID OF HEALTH AND CHROINC GENERALISED PERIODONTITIS WITH AND WITHOUT TYPE 2 DIABETES MELLITUS -A - CLINICO-BIOCHEMICAL STUDY - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/090868
Enrollment
90
Registered
2025-07-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications Health Condition 2: K053- Chronic periodontitis

Interventions

Intervention1: Non Surgical periodntal Therapy (Scaling ): NSPT will be done using piezoelectric ultrasonic scalers an all the study participants in Group 1 (healthy) for 4 weeks Intervention2: Non Su

Sponsors

Kaustubh Ram
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.age between 20 to 60 2.indivigual in which there is presence of at least 20 natural teeth 3.patients with Stage III grade B periodontitis. 4.Patients with healthy periodontium 5.sumjects with controlled T2DM 6. Subjects without T2DM

Exclusion criteria

Exclusion criteria: 1.individuals with other systemic disease other than controlled T2DM 2.Individuals who have received periodontal therapy in the last 6 months. 3.smokers 4.Pregnant/lactating mothers 5.individuals who had antimicrobial and Anti-inflammatory therapy in last 6 months

Design outcomes

Primary

MeasureTime frame
levels of Ghrelin and TNF- alpha in GCF after NSPTTimepoint: baseline and end of 3 months after NSPT

Secondary

MeasureTime frame
Plaque index , Gingival Index Bleeding on probing Probing Depth and clinical attachment lossTimepoint: baseline and end of 3 months after NSPT

Countries

India

Contacts

Public ContactKaustubh Ram

The Oxford Dental College, Bangalore

sunaina1096@gmail.com9845203336

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026