A Study Using Virtual Reality, Pain Education, and Movement Imagery to Reduce Pain, Fear of Movement, and Improve Daily Life in People with Knee Osteoarthritis

Effects of Virtual Reality versus Sham Virtual Reality Training Combined with Pain Neuroscience Education and Graded Motor Imagery on Pain, Quality of Life, Functional Disability, and Kinesiophobia in Knee Osteoarthritis: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090845

Enrollment

Registered

2025-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Virtual reality training combined with Pain Neuroscience Education and Graded Motor Imagery: The participants in the intervention group will receive immersive functional and mobility tr

Eligibility

Inclusion criteria

Inclusion criteria: I. Participants consent to a free participation to the study. II. All gender, aged between 40 and 64 years. III. Participants with a diagnosis, according to the American College of Rheumatology criteria 3 out of 6 symptoms present. IV. Kellgren and Lawrence classification Grade II- III or the Unilateral knee involvement. V. Participants with persistent chronic knee pain with symptoms for more than 3 months. VI. Participants reported pain as three or higher cm on a visual analog scale (VAS) during activity VII. Participants with adequate 24 points on the Mini-Mental State Examination (MMSE)

Exclusion criteria

Exclusion criteria: I. Any recent injury at hip, knee and ankle or surgery to the lower extremities within 6 Months. II. A history of systemic inflammatory arthritis, or septic arthritis. III. Participants with severe language comprehension deficits. IV.Corticosteroids in the knees in the last six months. V. Presence of cardiovascular disease VI. A history of epilepsy or other neurological disorders. VII. Participants with hearing loss, vestibular or balance disorder. VIII. Participants with visual impairment.

Design outcomes

Primary

Measure	Time frame
I. Visual Analogue Scale II. Knee injury and Osteoarthritis Outcome Score III. Short-Form 36-Item Health Survey (SF-36) IV. Tampa Scale of Kinesiophobia (TSK)Timepoint: 0, 10th week and 14th week (3 time lines)	—

Secondary

Measure	Time frame
Timed Up and GoTimepoint: 0, 10th week and 14th week (3 time lines);Dynamometer - Lower limb strength (JAMAR)Timepoint: 0, 10th week and 14th week (3 time lines);The Pain Catastrophizing Scale (PCS)Timepoint: 0, 10th week and 14th week (3 time lines)	—

Countries

India

Contacts

Public ContactDr Shetty Aparna Dinesh

KLE College of Physiotherapy, Hubballi, KAHER (Deemed-to-be-University), Belagavi

drshant24@gmail.com9448231520

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026