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A study done to find out the effect of depression on immunity by assessing immune status parameters at the start and after twelve weeks of antidepressant treatment

Cytotoxic T-cell exhaustion before and after twelve weeks trial of antidepressant treatment in first-onset major depressive disorder - NILL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/07/090830
Enrollment
90
Registered
2025-07-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F32- Major depressive disorder, singleepisode

Interventions

Intervention1: NILL: NILL Control Intervention1: Using ICD 11 criteria , ,Hamilton depression rating scale,Brief adherence rating scale,thase and rush staging used on first onse major depressive disor

Sponsors

Dr Shanty G Raj
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The patients of either gender aged between 18-60 years, who will attend psychiatry OPD or be admitted to psychiatry IPD with the diagnosis of first onset major depressive disorder (MDD) without psychotic symptoms according to ICD-11 criteria will be selected as MDD cases

Exclusion criteria

Exclusion criteria: 1. Any other psychiatric disorder 2. Substance use 3. Acute and chronic major physical illness 4. Any chronic medications except iron with folic acid and calcium with vitamin D supplementation 5. History of any infection during the last 6 weeks. 6. Electroconvulsive therapy or any other neuromodulation

Design outcomes

Primary

MeasureTime frame
PD-1 cell countsTimepoint: ONE YEAR

Secondary

MeasureTime frame
CTLA 4 CELL COUNTS TNF- ALPHA, IFN-GAMMA TREATMNET RESPONSE/TREATMENT RESISNTANT DEPRESSION Timepoint: ONE YEAR

Countries

India

Contacts

Public ContactDr Mahima Kapoor

delhi university

bckoner@hotmail.com9968604229

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026