To study the effect of Sevoflurane vs Desflurane in Spine surgery patients on cognition in the post-operative period.

Comparison of sevoflurane and desflurane for post-operative neurocognitive dysfunction in patients undergoing spine surgeries : A prospective randomized controlled close- ended assessor blinded clinical trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090809

Enrollment

126

Registered

2025-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: DESFLURANE: This study aims to compare the effects of sevoflurane and desflurane on post-operative cognitive dysfunction (POCD) in young adults undergoing spine surgery. POCD is a tempo

Eligibility

Inclusion criteria

Inclusion criteria: Age-young and middle aged adults ASA 1 and 2 Surgery of lumbar or thoracic spine surgery Level of education_at least till high school Preop MMSE greater than or equal to 23 Absence of serious hearing or vision impairment

Exclusion criteria

Exclusion criteria: Known cases of dementia or any psychiatric illness History of CVA with residual deficit Alcoholism , drug dependence Current use of benzodiazepine, antidepressants or psychotropic drugs Contraindication to use of inhalational agents Emergency nature of surgery Perioperative complications- requirements of post op ventilation, hemodynamic instability.

Design outcomes

Primary

Measure	Time frame
Incidence of POCD Assessed using a validated battery of neuropsychological tests administered preoperatively baseline (24 hrs prior) and postoperatively e.g postoperative day 7 and day 30. POCD is defined as a significant decline in cognitive test performance compared to baseline. The primary comparison is between the sevoflurane group and the desflurane group to evaluate the impact of the anesthetic agent on cognitive outcomes.Timepoint: preoperatively (24 hrs), post-op day 7, post op day 30.	—

Measure

Time frame

Incidence of POCD Assessed using a validated battery of neuropsychological tests administered preoperatively baseline (24 hrs prior) and postoperatively e.g postoperative day 7 and day 30. POCD is defined as a significant decline in cognitive test performance compared to baseline. The primary comparison is between the sevoflurane group and the desflurane group to evaluate the impact of the anesthetic agent on cognitive outcomes.Timepoint: preoperatively (24 hrs), post-op day 7, post op day 30.

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Secondary

Measure	Time frame
Change in MoCA Score Difference in MoCA scores from baseline to postoperative will be calculated to assess cognitive decline & compare between groups Association Between rSO2 & POCD Intraoperative rSO2 monitored using NIRS Correlation analysis between rSO2 values & incidence or severity of POCD in both groups Intraoperative Hemodynamic Parameters Heart rate mean arterial pressure MAP & oxygen saturation recorded at fixed intervals Compared between groups to assess physiological stability of each anesthetic Recovery Profile Time to eye opening extubation & orientation recorded Compared between groups to evaluate recovery & emergence Timepoint: 24hrs pre op 7 days post op 30 days post op	—

Measure

Time frame

Change in MoCA Score Difference in MoCA scores from baseline to postoperative will be calculated to assess cognitive decline & compare between groups Association Between rSO2 & POCD Intraoperative rSO2 monitored using NIRS Correlation analysis between rSO2 values & incidence or severity of POCD in both groups Intraoperative Hemodynamic Parameters Heart rate mean arterial pressure MAP & oxygen saturation recorded at fixed intervals Compared between groups to assess physiological stability of each anesthetic Recovery Profile Time to eye opening extubation & orientation recorded Compared between groups to evaluate recovery & emergence Timepoint: 24hrs pre op 7 days post op 30 days post op

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Countries

India

Contacts

Public ContactMayank Sharma

AIIMS NAGPUR

santosh72@aiimsnagpur.edu.in07694014955

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026