Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: Transcranial Direct Current Stimulation (tDCS): Participants will receive active transcranial direct current stimulation using 2 mA current applied for 20 min per session. Anode is plac
Sponsors
Dharwad Institute of Mental Health and Neurosciences (DIMHANS)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male patients aged between 18 and 55 years. 2. Diagnosed with Alcohol Dependence Syndrome as per ICD 11. 3. CIWA Ar score less than or equal to 10 at admission. 4. Not currently receiving anti craving medications. 5. OCDS score greater than 1. 6. Willing to provide informed consent and comply with study procedures.
Exclusion criteria
Exclusion criteria: a) Patients who do not give informed consent for the study. b) Patients with any other substance use disorder other than nicotine. c) Patients who have received modified electroconvulsive therapy (mECT) or any other neuromodulation treatment in the past 6 months. d) Patients with any significant neurological illness. e) Presence of medical implants (e.g., pacemakers, defibrillators, brain aneurysm clips, cochlear implants). f) Patients with any other contraindications to tDCS, including migraine and scalp skin lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in alcohol craving scores as measured by the Obsessive Compulsive Drinking Scale(OCDS).Timepoint: Baseline, 2 Weeks, 1 month post-intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relapse rate in patients with Alcohol Dependence Syndrome.Timepoint: 1 month post intervention;Change in gene expression levels (GRIN2B and GRIA1) from baseline to post-tDCS and follow-upTimepoint: Baseline, post tDCS intervention, 1 month post intervention.;Improvement in quality of life scoresTimepoint: 1 month post-intervention | — |
Countries
India
Contacts
Public ContactDr. Rajath Kumar K
DHARWAD INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES, DIMHANS
Outcome results
None listed