Health Condition 1: J80- Acute respiratory distress syndrome
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Ms Ashritha A Udupa
Eligibility
Inclusion criteria
Inclusion criteria: The study will include adult ARDS patients aged 18-80 years of either gender. ARDS should be diagnosed based on the new global definition of ARDS.
Exclusion criteria
Exclusion criteria: Patients of ARDS on Invasive mechanical ventilation (IMV) greater than 48 hours will be excluded. Patients with lung trauma, chest wall deformities where lung ultrasound may be unreliable will also be excluded. ARDS patients with immunosuppression as defined by a course of corticosteroids lasting more than two weeks at doses exceeding 20 mg of prednisolone per day, will be excluded. Patients with a history of solid organ or bone marrow transplantation, who have been treated with chemotherapy for any type of malignancy, any biological agent, prednisone equivalent of more than 10mg per day and 700 mg cumulative dose, antiproliferative agents and B cell or T cell depletion medications, will be excluded. Also, Pregnant patients with ARDS will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality at 28 days from ARDS diagnosis.Timepoint: 28 days from ARDS diagnosis | — |
Secondary
| Measure | Time frame |
|---|---|
| Prolonged Length of stay in ICU (greater than 14 days). To identify specific metabolites to reliably predict 28 day mortality in ARDS patients at an early stage of ARDS. Identification of metabolites to predict higher Driving pressure greater than or equal to 16 cm H2O in ARDS patients & also to identify sub phenotype 2 of ARDS.Timepoint: At Baseline, 2 weeks & 4 weeks. | — |
Countries
India
Contacts
Public ContactDr Souvik Chaudhuri
Kasturba Medical College, Manipal Academy of Higher Education, Manipal
Outcome results
None listed