Health Condition 1: K029- Dental caries, unspecified
Conditions
Interventions
Intervention1: Group1 and Group2
Group1-ECC with Abscess and Swelling
Group2-ECC: Venous blood samples will be collected from participating children at the time of their dental treatment. The collecte
Sponsors
Somya Seth
Eligibility
Inclusion criteria
Inclusion criteria: 1.Children aged 3 5 years. 2.Children who are systemically healthy. 3.Children classified into one of the following groups: Group 1: Children with Early Childhood Caries (ECC) presenting with clinical swelling or signs of dental abscess requiring pulpectomy. Group 2: Children with ECC without clinical swelling, requiring pulpectomy. Group 3: ECC with Dental Caries and No Pulpal Involvement 4.Parents or guardians willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Children with any systemic diseases or immunocompromised status. 2.Children who have received antibiotics or anti-inflammatory medication within the past 2 weeks. 3.Children with chronic medical conditions (e.g., asthma, diabetes, congenital heart disease). 4.Children with developmental dental anomalies that may affect immune or pulp response. 5.Children whose parents/guardians refuse consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To demonstrate the role of immunity in early childhood caries by comparing the expression levels of MCM2 7 and pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin six, and interleukin one beta) in serum samples of children with ECC with swelling, ECC without swelling, and healthy control.Timepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the correlation between the expression levels of MCM2 7 and pro-inflammatory cytokines with the clinical severity of Early Childhood Caries and the presence of swelling.Timepoint: Single Time-point | — |
Countries
India
Contacts
Public ContactRamesh R
Saveetha Dental College and Hospitals
Outcome results
None listed