Health Condition 1: F05- Delirium due to known physiological condition
Conditions
Interventions
Intervention1: Inhalational anesthesia: All patient will receive opioid free general anaethesia with inj. Midazolam 0.02 0.04 mg/kg, Inj. Dexmedetomidine 1mcg/kg infusion for 10 minutes followed by
Sponsors
AIIMS Nagpur
Eligibility
Inclusion criteria
Inclusion criteria: ASA I to III posted for elective surgeries requiring general anaesthesia
Exclusion criteria
Exclusion criteria: Patients with a medical history of neurological or neurovascular diseases such as delirium schizophrenia dementia or stroke. Dementia was defined as a Mini-Mental State Examination (MMSE) score of less than 17 for illiterate patients less than 20 for patients with 1 to 6 years of education and less than 24 for patients with 7 or more years of education Patients who were unable to read or had severe visual or auditory deficits Patients with a history of alcohol abuse and drug dependence Patients who were unwilling to comply with the study protocol or procedures. ASA more than IV Emergency surgeries Patients posted for neurosurgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess the incidence and severity of postoperative delirium in geriatric patients undergoing general anesthesia in both the groupTimepoint: day 0 to day 7 postoperatively twice a day | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the incidence and severity of postoperative delirium between the two anesthesia techniques.Timepoint: Day 0 to day 7 postoperatively twice a day;Measure cognitive function preoperatively and postoperatively using the mini mental state examination (MMSE) to assess the impact of anesthesia technique on cognitive outcomes.Timepoint: Preoperatively and postoperatively;Investigate serum biomarkers S100B and A2M associated with neural damage in the geriatric population to explore potential correlations with anaesthesia technique and postoperative deliriumTimepoint: preoperatively and postoperative day 1;Analyse the association between cognitive function, serum biomarkers, and the occurrence of postoperative deliriumTimepoint: at time of data analysis | — |
Countries
India
Contacts
Public ContactOmshubham Asai
AIIMS Nagpur
Outcome results
None listed