Comparison between the two pain reliving drugs (tramadol and nalbuphine) when added to a Local anaesthetic drug (Ropivacaine) in patients with knee replacement surgery

A comparative study of Epidural Nalbuphine vs Tramadol as an adjuvant to 0.2% Ropivaciane for post operative pain relief in unilateral total knee replacement surgeries. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090700

Enrollment

Registered

2025-07-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nalbuphine with ropivacaine: 0.2% Ropivacaine with 0.2mg/ml nalbuphine as an adjuvant for pain relief in post-operative period at 30 min, 1 hour, 2 hour, 4 hour, 6 hour, 12 hour and 24

Eligibility

Inclusion criteria

Inclusion criteria: Giving the consent ASA grade 1 and 2 Age groups 45-70 years

Exclusion criteria

Exclusion criteria: ASA 3/4 Refusal of consent Bleeding diathesis Contraindication to epidural anaesthesia Pregnancy and lactating mother

Design outcomes

Primary

Measure	Time frame
Post operative pain assessmentTimepoint: 30 mins 1 hr 2 hr 4 hr 6 hr 12 hr 24 hr	—

Secondary

Measure	Time frame
PONV , patient satisfactionTimepoint: 30 mins 1 hr 2 hr 4 hr 6 hr 12 hr 24 hr	—

Countries

India

Contacts

Public ContactDr Ruchi Baid

Rukmani Birla hospital

drruchibaid@gmail.com9828119109

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026