Better postoperative analgesic injection technique after knee surgeries

Ultrasound-Guided 4-in-1 Block Versus Combined Genicular Nerve and iPACK Blocks for Postoperative Analgesia in Total Knee Arthroplasty: A Randomised Clinical Trial - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090666

Enrollment

120

Registered

2025-07-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 4 in 1 block: 30 ml of 0.25 percent bupivacaine with 8 mg dexamethasone will be given in mid thigh Control Intervention1: Genicular nerve block, iPACK block: 3o ml of 0.25 percent bupiv

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1,2 and 3 BMI less than 30

Exclusion criteria

Exclusion criteria: Exclusion criteria: Patients unwilling to enrol for the study Change in the plan of anaesthesia Patients with a history of allergy to the drugs used in the study Patients with infection at the site of injection. Chronic opioid use Neuropathy Bilateral TKR Surgeries extending beyond 3 hours duration

Design outcomes

Primary

Measure	Time frame
To compare the Analgesic efficacy of ultrasound-guided 4-in-1 Block versus ultrasound-guided genicular nerve block with iPACK block postoperatively for patients undergoing total knee arthroplasty, measured by the Visual Analogue Scale.Timepoint: Postoperatively at 2,4,6,12 and 24 hours	—

Secondary

Measure	Time frame
To assess the requirement of postoperative rescue analgesiaTimepoint: End of surgery till 24 hours postoperatively;To assess the ease of the procedure in terms of durationTimepoint: From insertion of the needle till the needle is taken out after final injection;To evaluate the time to mobilisation postoperativelyTimepoint: From end of surgery to the time when the patient walks first;To assess the incidence of complications like hematoma and nerve injuryTimepoint: End of surgery till 24 hours postoperatively	—

Measure

Time frame

To assess the requirement of postoperative rescue analgesiaTimepoint: End of surgery till 24 hours postoperatively;To assess the ease of the procedure in terms of durationTimepoint: From insertion of the needle till the needle is taken out after final injection;To evaluate the time to mobilisation postoperativelyTimepoint: From end of surgery to the time when the patient walks first;To assess the incidence of complications like hematoma and nerve injuryTimepoint: End of surgery till 24 hours postoperatively

—

Countries

India

Contacts

Public ContactPradeesh Johny T

Aarupadai Veedu Medical College,Puducherry

pradeeshjohny@gmail.com9003549061

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026