Health Condition 1: I219- Acute myocardial infarction, unspecified Health Condition 2: K053- Chronic periodontitis
Conditions
Interventions
Control Intervention1: Assessment Of The Interplay Between Carotid Intima-media Thickness And Biomarkers FSTL-1, IL-6
Among Patients With Atherosclerotic
Cardiovascular Disease And Periodontal Dis
Sponsors
Suweadha. K
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for Stage III / IV Periodontitis Based on the classification system introduced by Kornman and Tonetti et al, 2018. Stage III: Interdental clinical attachment loss at site of greatest loss more than equal to 5mm. Radiographic bone loss extending to middle or apical third of root Tooth loss due to periodontitis less than equal to 4 teeth. Probing depth more than equal to 6mm. Extent Greater than 30 percent of teeth involved Generalized. Stage IV: Interdental clinical attachment loss at site of greatest loss more than equal to 5mm Radiographic bone loss extending to middle or apical third of root. Tooth loss due to periodontitis more than equal to teeth. Extent: Greater than 30 percent of teeth involved Generalized. Atherosclerosis in this study is defined as an event of Acute Myocardial Infarction, Acute Coronary Syndrome, patients with defined coronary artery disease (Coronary angiography) and patients post bypass and post stenting. Patients with aortic aneurysms (pathogenesis-atherosclerosis). Inclusion criteria for cardiovascular patients. History of angina and not consuming lipid lowering drugs (statins). Borderline high to high lipid profile inclusive of total cholesterol, Triglycerides and LDL (As per NCEP-ATP III classification) Total cholesterol level above 200mg/dL Triglycerides above 150 mg/dL. HDL above 60 mg/dL. LDL above 130 mg/ dL.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients with immunodeficiency disorders. Patients with other systemic inflammatory condition like sepsis, pneumonia, pleural effusion, intra-abdominal infections, inflammatory bowel disorders, inflammatory rheumatoid disorders, chronic kidney disease, Diabetes, cancers, COPD, asthma, HIV and hepatitis will be excluded from the study. History of periodontal treatment within the last 6 months. History of antibiotic therapy in the past 3 months. Subjects who are not willing to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether increased carotid intima-media thickness is associated with elevated levels of FSTL-1 and IL-6 in patients having both atherosclerotic cardiovascular disease and periodontal disease.Timepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactSuweadha K
SRM Dental College
Outcome results
None listed