A comparison of how well mouth gels made from oregano oil, magnolia oil, cranberry oil, and tea tree oil work when used directly on the gums to treat early to moderate gum disease.

Comparative evaluation of clinical efficacy of Origanum oil, Magnolia oil, Cranberry oil and Tea tree oil oral in-situ gels as local drug delivery in the treatment of Stage -I and Stage-II Periodontitis - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090645

Enrollment

Registered

2025-07-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Origanum vulgare oil oral in-situ gel: Carvacrol is a phenolic monoterpenoid, produced by many herbs, the best known of which are Origanum vulgare. Carvacrol has long been recognized as

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with Stage I and Stage II Periodontitis. 2.Patients within the age group of 30 to 55 years of age for both genders. 3.Subjects with no history of allergies to the components used in the study 4.Apparently healthy individuals 5.Patients who are willing to give consent.

Exclusion criteria

Exclusion criteria: 1.Patients with habits like any form of tobacco, or alcohol consumption. 2.Systemically compromised patients 3.Pregnant women or lactating mothers 4.Patients who are on medication that influences Periodontal health. 5.Patients who will not be able to be attend for follow up visits

Design outcomes

Primary

Measure	Time frame
1. Improvement in clinical attachment level 2.Reduction of Periodontal Pocket Probing DepthTimepoint: baseline,1 month and 3 months	—

Secondary

Measure	Time frame
better wound healing (PISA index)Timepoint: baseline,1 month and 3 months	—

Countries

India

Contacts

Public ContactDr Boyapati Ramanarayana

SIBAR INSTITUTE OF DENTAL SCIENCES

dr.ramanarayana@gmail.com09490144365

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026