A study comparing chorion and collagen membrane used with DFDBA bone graft to treat gum disease related bone loss between tooth roots,to see which helps healing better.

A comparative evaluation of the efficacy of demineralized freeze-dried bone allograft (DFDBA) in conjunction with chorion membrane versus collagen membrane for the treatment of grade II furcation defects- a randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090629

Enrollment

Registered

2025-07-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: CHORION MEMBRANE: The Chorion Membrane is a natural biomaterial for periodontal regeneration, acting as a biocompatible scaffold that promotes tissue regeneration and improves clinical

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients in the age group of 20 to50 year. Presence of clinical and radiographic Grade II buccal furcation defects. Patients who were diagnosed with buccal degree II furcation defects as their mandibular first and second molars with a vertical probing depth (PPD) greater than or equal to 5 mm and intraoral periapical radiographs showing radiolucency in the furcation areas of the above teeth were included. Participants who agreed to participate and signed an informed consent form.

Exclusion criteria

Exclusion criteria: Antimicrobial medications or antibiotic mouth rinses taken in past 3 months prior to study. Has undergone any periodontal surgery in the past 3 months. Medication that would induce gingival enlargement, immunosuppressants. Pregnant women / Lactating mothers. Smokers & Tobacco chewers

Design outcomes

Primary

Measure	Time frame
Although both materials groups aid to bone regeneration and periodontal healing,a statistically and clinically significant difference in the gain of Relative Clinical Attachment Level (RCAL), reduction in Vertical and Horizontal Probing Depths (VPD and HPD), and radiographic bone fill between the DFDBA + chorion membrane group and the DFDBA + collagen membrane group at baseline, 3 months, and 6 months post-surgery in Grade II furcation defects is expected.Timepoint: Follow up at baseline,3 months and 6 months	—

Measure

Time frame

Although both materials groups aid to bone regeneration and periodontal healing,a statistically and clinically significant difference in the gain of Relative Clinical Attachment Level (RCAL), reduction in Vertical and Horizontal Probing Depths (VPD and HPD), and radiographic bone fill between the DFDBA + chorion membrane group and the DFDBA + collagen membrane group at baseline, 3 months, and 6 months post-surgery in Grade II furcation defects is expected.Timepoint: Follow up at baseline,3 months and 6 months

—

Secondary

Measure	Time frame
A measurable and statistically significant difference in clinical parameters Gingival Index (GI), Plaque Index (PI), Periodontal Probing Depth (PPD), and Relative Clinical Attachment Level (RCAL) from baseline to 3 and 6 months post-surgery, indicating the effectiveness of the treatment modalities under evaluation. Timepoint: Follow up at baseline,3 months and 6 months	—

Countries

India

Contacts

Public ContactShilpi Gupta

Santosh Deemed To Be University

drsauravsingh4@gmail.com9826483854

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026