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Exploring Brahmi Ghrita Nasya for Cognitive Impairment Following ECT in Depression Patients

A Randomized Controlled Study of Brahmi Ghrita Nasya (BGN) for the Amelioration of Cognitive Impairment Following Electroconvulsive Therapy in Patients with Depression. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/090561
Enrollment
70
Registered
2025-07-09
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G- Mental Health

Interventions

None listed

Sponsors

Dr Vandana PV
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed patients with depression who are indicated for bifrontal electroconvulsive therapy (ECT) and are undergoing a minimum of three ECT sessions Patients who are cooperative for baseline cognitive assessment Age between 18 and 65 years

Exclusion criteria

Exclusion criteria: Uncontrolled diabetes mellitus or hypertension Age below 18 years or above 65 years Pregnant women Presence of any severe physical illness Intellectual disability disorder Patients undergoing bitemporal ECT or unilateral ECT Pre-existing cognitive disorder Neurological illnesses Substance use disorder (excluding nicotine dependence) Vitamin B12 deficiency or thyroid deficiency disorders

Design outcomes

Primary

MeasureTime frame
Visual and autobiographical memories were tested using subsets of the B4ECT ReCoDe.Timepoint: Base line, after3 rd ECT, after 6th ECT, after last ECT

Secondary

MeasureTime frame
Verbal memory and working memory were assessed using the Rey Auditory Verbal Learning Test (RAVLT), Digit Span, and Spatial Span tests. Verbal fluency was evaluated using the Controlled Oral Word Association Test (COWAT). Adverse effects were measured by UKU scale.Timepoint: Baseline, after 3rd ECT, after 6th ECT, after last ECT.

Countries

India

Contacts

Public ContactDr Vandana PV

NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES BANGLORE

ayurkishore@yahoo.com9845829174

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026