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To Compare two agents which are considered to form hard tissue within the tooth.

Comparative Clinical and Radiographic Evaluation of 3Mixtatin and MTA as Pulp Capping Agents: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/090523
Enrollment
38
Registered
2025-07-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: 3Mixtatin: It is a combination of 100mg Metronidazole, 100mg Ciprofloxacin, 100mg Cefixime, and 2mg Simvastatin. These 4 agents are mixed with the help of saline and made into a paste.

Sponsors

Malla Reddy Dental College for Women
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Deep carious lesion penetrating three-quarters or more into dentine as identified with periapical (PA) radiograph; Clinically mICDAS score 4 (Banerjee and Watson 2011) 2. Clinical symptoms of reversible pulpitis. 3. Presence of at least 2/3rds of root length radiographically, & restorability of selected teeth were also confirmed. 4. Positive pulp response to electric pulp test or thermal stimulation. 5. No PA changes on PA radiographs.

Exclusion criteria

Exclusion criteria: 1. Signs or symptoms more severe than reversible pulpitis. 2. Radiographic evidence of pulp degeneration such - widening of periodontal ligament space, internal and external resorption of the root (IRR and ERR), 3. Pulp necrosis 4. Furcal radiolucency or inter radicular bone destruction (FR/IBD) and/or 5. Periapical bone destruction (PBD). 6. Pregnant women (in view of requirements for radiographs). 7. Patients unable to give consent.

Design outcomes

Primary

MeasureTime frame
To compare and evaluate the clinical and radiographic efficacy of 3Mixtatin and MTA when used as pulp capping agents in permanent teeth using the CBCT. Timepoint: 1. Pre-operative PA radiograph and CBCT, followed by post-operative PA radiograph. 2. 1 month follow-up: PA radiograph. 3. 3 months follow-up: PA radiograph and CBCT taken. 4. 6 months follow-up: PA radiograph and CBCT taken.

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactS Srija Mili

MALLA REDDY DENTAL COLLEGE FOR WOMEN

drswathi.endo@gmail.com09866021672

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026