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Effect of longer prone positioning on breathing and kidney health in ICU patients with severe lung injury

Utility of extended sessions of prone ventilation among prone ventilated ARDS (Acute Respiratory Distress Syndrome) patients in the reduction of pulmonary and renal inflammatory biomarkers and mortality outcomes A Prospective observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/07/090515
Enrollment
45
Registered
2025-07-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil

Sponsors

Ms Shruthi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: (i) Adult patients of moderate-severe ARDS as per the New Global Definition of ARDS (ii) Patients aged 18 years or above who are advised for prone position ventilation (iii) ARDS patients with PaO2/FiO2 less than 150 with PEEP greater than 5 cmH2O with FiO2 of at least 0.6 and on invasive mechanical ventilation

Exclusion criteria

Exclusion criteria: (i) Patients with a history of solid organ or bone marrow transplantation, who have been treated with chemotherapy for any type of malignancy, any biological agent, prednisone equivalent of more than 10 mg/day and 700 mg cumulative dose, antiproliferative agents and B-/T-cell depletion medications. (ii) Pregnant patients (iii) Patient with the history of Cardiac arrest (iv) Patients referred for palliative care or discharged against medical advice. (v) Patients diagnosed with chronic kidney disease (CKD) (vi) Patients with penetrating chest injuries, pneumothorax at the time of recruitment. (vii) Patients in the study arm who had to be turned to supine position before 24 hours of continuous prone position ventilation. (viii) Patients who expire within 24 hours of prone position ventilation initiation

Design outcomes

Primary

MeasureTime frame
A reduction of at least 25% in the pulmonary and renal inflammatory biomarkersTimepoint: After 16-20 hours of Prone position ventilation—

Secondary

MeasureTime frame
Renal replacement therapy requirementTimepoint: 28 days of ICU stay;MortalityTimepoint: 28 days of ICU stay—

Countries

India

Contacts

Public ContactDr Souvik Chaudhuri

Kasturba Medical College, Manipal

souvik.chaudhuri@manipal.edu9937178620

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026