Retrospective analysis to find whether a relationship exists between the timing of chest imaging and the finding of a positive diagnosis that can change the treatment of patients admitted to the intensive care unit with nonimproving lower respiratory tract infection.

Association of clinically significant diagnostic yield with the timing (early versus late) of computed tomography of the chest in critically ill patients with nonresponding pneumonia: A retrospective analysis from a tertiary care center. - NIL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

CTRI

Registry ID

CTRI/2025/07/090504

Enrollment

268

Registered

2025-07-08

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J168- Pneumonia due to other specified infectious organisms

Interventions

Intervention1: Nil: Nil

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients admitted to the ICU who underwent CT chest for evaluation of nonresponding pneumonia after 72 hours of starting or a change in the antibiotic therapy. 2.If multiple imaging is being done for the same patient, the outcome of each scan will be counted separately.

Exclusion criteria

Exclusion criteria: 1.Patients who did not undergo any CT chest during their ICU stay. 2.Patients who underwent CT chest before or within 72 hours of the commencement of antibiotic therapy. 3.Patients with incomplete data on the day of commencement of antibiotic therapy before admission. 4.CT scan done before ICU admission. 5.CT scans performed for indications other than NRP or for interventional imagery, such as a CT pulmonary embolism or CT scan-guided procedures that the patient underwent. 6.Pregnancy 7.Known case of pulmonary tuberculosis, malignancy and bronchiectasis.

Design outcomes

Primary

Measure	Time frame
To evaluate the association of treatment change event rate with the timing of CT chest (early versus late) in critically ill patients with nonresponding pneumonia.Timepoint: After approval by CTRI, the data will be collected from ICU charts will be reviewed by retrospective chart review at the following timepoints: 1.On the day of ICU admission for baseline data. 2.On the day of CT chest imaging and next day for the diagnostic yield and any treatment change event 3.Till the last day of ICU stay for estimation of duration of ICU stay, mechnical ventilation outcomes and mortality.	—

Measure

Time frame

To evaluate the association of treatment change event rate with the timing of CT chest (early versus late) in critically ill patients with nonresponding pneumonia.Timepoint: After approval by CTRI, the data will be collected from ICU charts will be reviewed by retrospective chart review at the following timepoints: 1.On the day of ICU admission for baseline data. 2.On the day of CT chest imaging and next day for the diagnostic yield and any treatment change event 3.Till the last day of ICU stay for estimation of duration of ICU stay, mechnical ventilation outcomes and mortality.

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Secondary

Measure	Time frame
1.To compare the sensitivity & specificity of the early versus late CT chest. 2.To compare the correlation of the CT findings with the final microbiological diagnosis in early versus late CT chest groups. 3.To evaluate the following differences in those who underwent early versus late CT chest for the evaluation of NRP. -Difference in the time to clinical stability -Difference in the length of mechanical ventilation -Difference in length of ICU stay -Difference in ICU mortality 4.To identify the clinical predictors associated with a positive diagnosis on CT chest in patients with NRP.Timepoint: After approval by CTRI, the data will be collected from ICU charts will be reviewed by retrospective chart review at the following timepoints: 1.On the day of ICU admission for baseline data. 2.On the day of CT chest imaging & next day for the diagnostic yield & any treatment change event 3.Till the last day of ICU stay for estimation of duration of ICU stay, mechnical ventilation outcomes & mortality.	—

Measure

Time frame

1.To compare the sensitivity & specificity of the early versus late CT chest. 2.To compare the correlation of the CT findings with the final microbiological diagnosis in early versus late CT chest groups. 3.To evaluate the following differences in those who underwent early versus late CT chest for the evaluation of NRP. -Difference in the time to clinical stability -Difference in the length of mechanical ventilation -Difference in length of ICU stay -Difference in ICU mortality 4.To identify the clinical predictors associated with a positive diagnosis on CT chest in patients with NRP.Timepoint: After approval by CTRI, the data will be collected from ICU charts will be reviewed by retrospective chart review at the following timepoints: 1.On the day of ICU admission for baseline data. 2.On the day of CT chest imaging & next day for the diagnostic yield & any treatment change event 3.Till the last day of ICU stay for estimation of duration of ICU stay, mechnical ventilation outcomes & mortality.

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Countries

India

Contacts

Public ContactMeenupriya Arasu

All India Institute of Medical Sciences, New Delhi

vimirewari@gmail.com9818304880

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026

Retrospective analysis to find whether a relationship exists between the timing of chest imaging and the finding of a positive diagnosis that can change the treatment of patients admitted to the intensive care unit with nonimproving lower respiratory tract infection.

Conditions

Related papers

Interventions

Sponsors

Eligibility

Inclusion criteria

Exclusion criteria

Design outcomes

Primary

Secondary

Countries

Contacts

Outcome results