Effect of Apfel score prophylaxis versus Universal prophylaxis for post-operative nausea and vomiting

To evaluate the effectiveness of Apfel score based prophylaxis versus Universal prophylaxis to reduce the need of antiemetic for post-operative nausea and vomiting in patients under general anaesthesia at SMS Medical College Jaipur - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090470

Enrollment

420

Registered

2025-07-08

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Assessing the risk for PONV preoperatively through APFEL score: Only patients with moderate (score 2)and high (scores 3,4) risk according to the Apfel score will receive PONV prophylax

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patient schedule for various elective surgery under general anaesthesia required endotracheal intubation. 2 Patient willing to give written informed consent. 3.Body mass index less than 30kg/m2. 4.American society of anaesthesiologist (ASA) class 1 and 2.

Exclusion criteria

Exclusion criteria: 1.Patient required post operative mechanical ventilation . 2.Patient with known allergy to ondansetron. 3.Patient in whom metoclopramide has been used for aspiration prophylaxis.

Design outcomes

Primary

Measure	Time frame
1.To assess and compare the number of patient having post operative nausea and vomiting (PONV) between the two groups. 2.To assess and compare the dose of rescue antiemetic (inj.metaclopramide10mgiv,inj dexamethasone0.2mg/kg iv) required in first 24 Hours post operatively between the two groupsTimepoint: 1.Episodes of Nausea and vomiting at the end of 24 hours after the surgery. 2. Number of doses of anti emetic given at the end of 24 hours after the surgery.	—

Measure

Time frame

1.To assess and compare the number of patient having post operative nausea and vomiting (PONV) between the two groups. 2.To assess and compare the dose of rescue antiemetic (inj.metaclopramide10mgiv,inj dexamethasone0.2mg/kg iv) required in first 24 Hours post operatively between the two groupsTimepoint: 1.Episodes of Nausea and vomiting at the end of 24 hours after the surgery. 2. Number of doses of anti emetic given at the end of 24 hours after the surgery.

—

Secondary

Measure	Time frame
To assess and compare the difference in proportion of patient having side effects (palpitations, constipation, headache etc.)if between two groupsTimepoint: At the end of 24 hours after the surgery .	—

Countries

India

Contacts

Public ContactVipin Kumar Yadav

Sawai Man Singh Medical College and Attached hospital

samridhinanda@gmail.com9680565399

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026