Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Colistin plus tigecycline: Combination of tigecycline loading dose of 200 mg IV and then (100 mg IV BD) plus colistin 9 Lakh IU Loading f/b (4.5 lakh IV BD)
Control Intervention1: Colis
Sponsors
All India Institute of Medical Sciences Patna Bihar
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients with VAP/HAP/BSI who are admitted with culture positive Acinetobacter baumanii in medical ICU. 2. Those who give consent for the study
Exclusion criteria
Exclusion criteria: 1. Non-Acinetobacter baumanii VAP/HAP/BSI admitted in ICU 2. Superimposed infection during the treatment of CRAB infection 3. Extremes of age-Age less than 18 and more than 70 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality Timepoint: Mortality will be seen within 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Comorbid conditions, Physiological scores (APACHE II), microbiological clearance (14 & 28 days),Clinical response to drugs (14 & 28 days) Timepoint: All the comorbid conditions like Diabetes, Hypertension, CVA, neuromuscular disease, valvular heart disease will be noted on day 0 of admission APACHE II score on day 0 of admission Microbiological response success will be assessed by clearance of organism in repeat culture at day 14 & 28 Clinical response success will be assessed by improvement in Glasgow coma scale (GCS), Improvement in P/F ratio, decrease in ionotropic support at day 14 & 28 | — |
Countries
India
Contacts
Public ContactDr Ajeet Kumar
AIIMS Patna
Outcome results
None listed