Using intravenous and nebulized lignocaine before surgery to reduce the increase in blood pressure during laryngoscopy and intubation in women with severe preeclampsia undergoing a cesarean section.

Efficacy of preoperative intravenous and nebulized lignocaine for attenuation of pressor response to laryngoscopy and intubation in severe preeclampsia undergoing lower segment cesarian section a randomized double blind study. - Randomized, parallel group trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090446

Enrollment

Registered

2025-07-08

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O141- Severe pre-eclampsia

Interventions

Intervention1: Nebulized and intravenous lignocaine (anaesthetic drug): Intravenous Cannula inserted as per standard protocol Intervention2: Nil: Nil Intervention3: Nil: Nil Control Intervention1: Lig

Eligibility

Inclusion criteria

Inclusion criteria: Parturients with severe preeclampsia (Systolic blood pressure more than 160 mmhg or diastolic blood pressure more than 110 mmhg at two occasions at least 4 hour apart, new onset headache or visual disturbance, platelet less than1 lakh, epigastric pain) undergoing Lower Segment cesarian section 2. Mallampatti grading I and II

Exclusion criteria

Exclusion criteria: 1. More than one attempt of intubation 2. Time taken for intubation more than 40 seconds 3. Any cardiac diseases, uncontrolled diabetes mellitus 4. Creatinine more than 2mg/dl, elevated liver enzyme

Design outcomes

Primary

Measure	Time frame
1.Difference in Systolic blood pressure 2.Difference in Diastolic blood pressure 3.Difference in mean arterial pressure 4.Difference in heart rateTimepoint: Baseline (Before nebulization) T0 Before iv injection (T1) Before induction (T2) After induction & before laryngoscopy (T3) After laryngoscopy & before intubation(T4) After intubation (T5) 1MIN (T6) 1 MIN 30 SEC (T7) 2MIN (T8) 2 MIN 30 SEC (T9) 3 MIN (T10) 3MIN 30 SEC (T11) 4MIN (T12) 4MIN 30 SEC (T13) 5MIN	—

Measure

Time frame

1.Difference in Systolic blood pressure 2.Difference in Diastolic blood pressure 3.Difference in mean arterial pressure 4.Difference in heart rateTimepoint: Baseline (Before nebulization) T0 Before iv injection (T1) Before induction (T2) After induction & before laryngoscopy (T3) After laryngoscopy & before intubation(T4) After intubation (T5) 1MIN (T6) 1 MIN 30 SEC (T7) 2MIN (T8) 2 MIN 30 SEC (T9) 3 MIN (T10) 3MIN 30 SEC (T11) 4MIN (T12) 4MIN 30 SEC (T13) 5MIN

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Secondary

Measure	Time frame
1.Incidence and grade of coughing during extubation 2.Incidence and grade of hoarseness 3.Incidence and grade of post operative sorethroat 4.Neonatal outcome (APGAR score)Timepoint: Grade of cough at from the end of surgery to 5 minute after extubation Hoarseness at 1 & 2 hour after PACU admission Post operative sore throat at 1 & 2 hour after PACU admission APGAR score at 1 & 5 minute after baby delivered	—

Measure

Time frame

1.Incidence and grade of coughing during extubation 2.Incidence and grade of hoarseness 3.Incidence and grade of post operative sorethroat 4.Neonatal outcome (APGAR score)Timepoint: Grade of cough at from the end of surgery to 5 minute after extubation Hoarseness at 1 & 2 hour after PACU admission Post operative sore throat at 1 & 2 hour after PACU admission APGAR score at 1 & 5 minute after baby delivered

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Countries

India

Contacts

Public ContactDr Pratibha Jain Shah

Pt J N M Medical college Raipur

prati_jain@rediffmail.com9827276620

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026