Comparing Buffered vs. Non-Buffered 4% Articaine for Pain Relief in Kids After a Common Dental Injection

Comparative evaluation of buffered 4% articaine versus 4% articaine in pain perception following labial infiltration in children. - NIL

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090391

Enrollment

Registered

2025-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K14- Diseases of oral cavity and salivary glands

Interventions

Intervention1: Articaine buffered with 8.4% sodium bicarbonate: 1ml of buffered 4% articaine with 1:100,000 epinephrine will be administered over a period of 60 seconds Control Intervention1: Articain

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients willing to participate in the study. 2. Patients exhibiting Frankl s behaviour rating 3 or 4. 3. Patients requiring non-surgical extraction of primary maxillary incisors. 4. Primary maxillary incisors that cannot be restored.

Exclusion criteria

Exclusion criteria: 1. Patients with a known history of allergy to any of the constituents present in the local anesthetic agent. 2. History of medically compromised conditions. 3. Presence of acute dento-alveolar infection at the site of injection. 4. History of dental treatment in the past 6 months. 5. Presence of pathological lesion involving primary maxillary incisors. 6. Presence of pain in relation to primary maxillary incisors. 7. Patients who have taken analgesics in the last 24 hours.

Design outcomes

Primary

Measure	Time frame
To compare the pain perception in pediatric patients following labial infiltration using buffered 4% articaine versus conventional (non-buffered) 4% articaine, as assessed by validated pain scales during labial infiltration.Timepoint: baseline	—

Secondary

Measure	Time frame
nilTimepoint:	—

Countries

India

Contacts

Public ContactDR PRIYA SUBRAMANIAM

THE OXFORD DENTAL COLLEGE

panditsusaanaaustine99@gmail.com8332821028

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026