Comparison of nebulized ropivacaine 0.5% with nebulized lignocaine 2% on changes in the mean arterial pressure on intubation in patients undergoing surgery under general anaesthesia: A comparative randomized controlled study.

Comparison of nebulized ropivacaine 0.5 percent with nebulized lignocaine 2 percent on the mean arterial pressure on intubation in patients undergoing surgery under general anaesthesia: A comparative randomized controlled study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090317

Enrollment

105

Registered

2025-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Nebulised Ropivacaine 0.5%: Nebulised Ropivacaine 0.5% of volume 5ml by nebuliser mask at 10L per minute oxygen flow Control Intervention1: Nebulised Lignocaine 2%: Nebulised Lignocaine

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists Classification (ASA) of 1 or II, aged 18-60 years, scheduled for elective surgeries under general anesthesia.

Exclusion criteria

Exclusion criteria: mental illness allergies to relevant drug anticipated difficult airway.

Design outcomes

Primary

Measure	Time frame
Comparing between 2 groups the changes in mean arterial pressure on intubation in patients undergoing sure grey under general anesthesia which inturn assess the sympathetic response to intubation.Timepoint: Baseline before the procedure of nebulization After nebulization. Before tracheal intubation. After tracheal intubation 4-5 minutes after tracheal intubation At the closure of skin incision Immediately after tracheal extubation 7-5 minutes after tracheal extubation.	—

Measure

Time frame

Comparing between 2 groups the changes in mean arterial pressure on intubation in patients undergoing sure grey under general anesthesia which inturn assess the sympathetic response to intubation.Timepoint: Baseline before the procedure of nebulization After nebulization. Before tracheal intubation. After tracheal intubation 4-5 minutes after tracheal intubation At the closure of skin incision Immediately after tracheal extubation 7-5 minutes after tracheal extubation.

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Secondary

Measure	Time frame
Compare the cough response between 2 groupsTimepoint: During extubation;Compare the changes in heart rate between 2 groups on intubationTimepoint: TO baseline before the procedure of nebulization Tl after nebulization T2 before tracheal intubation T3after tracheal intubation T4-5 minutes after tracheal intubation TS at the closure of skin incision T6 immediately after tracheal extubation T7-5 minutes after tracheal extubation	—

Measure

Time frame

Compare the cough response between 2 groupsTimepoint: During extubation;Compare the changes in heart rate between 2 groups on intubationTimepoint: TO baseline before the procedure of nebulization Tl after nebulization T2 before tracheal intubation T3after tracheal intubation T4-5 minutes after tracheal intubation TS at the closure of skin incision T6 immediately after tracheal extubation T7-5 minutes after tracheal extubation

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Countries

India

Contacts

Public ContactShravya M

Dr SN Medical college Jodhpur

sarita.janweja@gmail.com9829116420

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026