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Testing Metronidazole and Its Mixtures to Clean Infected Root Canals in Childrens Teeth

Comparative evaluation of antibacterial efficacy of metronidazole and its combinations as irrigating solutions in root canals of primary teeth - A clinical trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/090316
Enrollment
48
Registered
2025-07-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: metronidazole and its combinationation with ciprofloxacin irrigation on primary teeth: Evaluate the antibacterial efficacy of metronidazole and its combinations as irrigating solution

Sponsors

dr.Anushka Manish Choche
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1Patients who belonged to Frankels 3 and Frankels 4 behavioral rating scale 2 Patients between the age of 4to9 years of both sexes with no history of systemic illness 3 Teeth with carious pulpal involvement which are indicated for pulpectomy 4 Teeth with at least two third root length intact 5 Teeth which can be restored 6 Patients who willfully give assent and for whom the parents or guardian will give the written informed consent to be a part of this study

Exclusion criteria

Exclusion criteria: 1 Teeth with pre-shedding mobility or abnormal pathologic mobility 2 Teeth with root resorption which is more than one third of the root length 3 Patients who were on systemic antibiotics within last 2 weeks 4 Teeth which show perforation of the pulpal floor 5 Teeth with interdental bone loss 6 Teeth with pathologic lesions like radicular granuloma or cyst 7 Patient with special health care needs 8 Patients who are not willing or for whom the parent or the guardian did not give the written informed consent for the treatment 9 Patients who are suffering from any other debilitating systemic illness 10 Patients with known history of allergic reaction to medications and materials used in the study

Design outcomes

Primary

MeasureTime frame
Evaluating antibacterial efficacy of Metronidazole and its combinations as irrigating solutions in primary teeth to obtain an effective root canal disinfection.Timepoint: day 1 that is after access opening and day 3 that is after biomechanical preparation and before obturation

Secondary

MeasureTime frame
evaluating total bacterial count after access opening & after biomechanical preparation & before obturation using respective intracanal medicamentsTimepoint: day 1 & at day 3

Countries

India

Contacts

Public ContactDr Jyothsna V Setty

ri Siddhartha Dental College and Hospital

jyothsnasrikanth@gmail.com9449819468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026