Comparing the use of buffered lignocaine ( this is a drug use to prevent pain) and saline in the breathing tube to reduce cough, sore throat, and hoarseness in smokers waking up from surgery under general anesthesia.

Comparison of intracuff alkalinized 2 percent lignocaine with saline in ETT on emergence of cough, sore throat and hoarseness in smokers undergoing surgery in general anaesthesia. - NIL

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090276

Enrollment

Registered

2025-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: Alkalinised 2% lignocaine: Pateint endotracheal tube cuff will be filled with alkalinized lignocaine in which 6.5 ml (130 mg) 2% lignocaine made alkalinized with 1.4% sodium bicarbonat

Eligibility

Inclusion criteria

Inclusion criteria: Smokers for a period longer than 5 years consuming atleast 5 cigarettes/bidis a day undergo surgery under general anaesthesia lasting for more than 2 hours.

Exclusion criteria

Exclusion criteria: 1.Patients with difficult airway i.e. Modified Mallampatti class III/IV. 2.Patients with history suggestive of Gastro esophageal reflux. 3.Patients with history of laryngeal or tracheal surgery and history of asthma, cardiovascular disease. 4.Recent respiratory infection. 5.Requirement of more than one attempt for endotracheal intubation. 6.Patients who need nasogastric tube intraoperatively. 7.Surgery lasting less than 40 min. 8.No consent for study.

Design outcomes

Primary

Measure	Time frame
1.The study will demonstrate that inflation of the ETT cuff with alkalinized 2% lignocaine is superior to normal saline in decreasing the incidence of cough, sore throat, and hoarseness of voice during the postoperative period in smokers undergoing surgery in general anaesthesia. 2.Efficacy of intracuff alkalinised lignocaine in attenuation oh haemodynamic stress response compared to intracuff normal saline is significantly higher in ASA-1 and 2 patients with respect to HR, SBP, DBP and MAP.Timepoint: These outcomes are based on observations made after intubating and inflating the endotracheal cuff of patient to extubation and follow up after 1, 6 and 12 hours in postoperative period.	—

Measure

Time frame

1.The study will demonstrate that inflation of the ETT cuff with alkalinized 2% lignocaine is superior to normal saline in decreasing the incidence of cough, sore throat, and hoarseness of voice during the postoperative period in smokers undergoing surgery in general anaesthesia. 2.Efficacy of intracuff alkalinised lignocaine in attenuation oh haemodynamic stress response compared to intracuff normal saline is significantly higher in ASA-1 and 2 patients with respect to HR, SBP, DBP and MAP.Timepoint: These outcomes are based on observations made after intubating and inflating the endotracheal cuff of patient to extubation and follow up after 1, 6 and 12 hours in postoperative period.

—

Secondary

Measure	Time frame
Intraoperative changes in Blood pressure, Heart rate & Saturation.Timepoint: Measured in every 10 minutes till the surgery end.	—

Countries

India

Contacts

Public ContactDr Neelima Tandon

Gajra Raja Medical College , Gwalior , Madhya Pradesh

dr.neelimatandon21@gmail.com9826215586

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026

Comparing the use of buffered lignocaine ( this is a drug use to prevent pain) and saline in the breathing tube to reduce cough, sore throat, and hoarseness in smokers waking up from surgery under general anesthesia.

Conditions

Related papers

Interventions

Sponsors

Eligibility

Inclusion criteria

Exclusion criteria

Design outcomes

Primary

Secondary

Countries

Contacts

Outcome results