Health Condition 1: M438- Other specified deforming dorsopathies
Conditions
Interventions
Intervention1: PRP + McKenzie Exercises: Total duration: 4 weeks.
This group will receive:
PRP Therapy: A single ultrasound-guided transforaminal epidural injection of 2 3 mL of autologous PRP prepa
Sponsors
Dr Ehsanur Rahman
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults aged 25 to 55 years, both sexes. 2. Clinically diagnosed L5 to S1 lumbar disc herniation confirmed by MRI (disc protrusion or bulge, with or without nerve root compression). 3. Chronic low back pain with or without radiating leg pain, consistent with radiculopathy, for more than 6 weeks. 4. Pain intensity of 3 or above on the Visual Analogue Scale (VAS). 5. Inadequate response to prior conservative treatments (e.g., rest, oral medication, or physiotherapy without supervision). 6. Positive Straight Leg Raise test or neurological signs such as sensory change, weakness, or altered reflex. 7. Platelet count within the normal range (150,000 to 400,000 per microliter). 8. Not currently recommended for surgery or prefers non-surgical treatment. 9. Provides written informed consent to participate.
Exclusion criteria
Exclusion criteria: 1. Calcified disc herniation or hard disc on imaging 2. Cauda equina syndrome (e.g., urinary retention, saddle anesthesia) 3. Other spinal pathologies, including tumors, spinal infections (e.g., tuberculosis), or vertebral fractures 4. Previous lumbar spine surgery at the affected level 5. Uncontrolled diabetes mellitus 6. Pregnancy 7. Contraindications to PRP or exercises: Bleeding disorders (e.g., haemophilia), Current anticoagulant use (except low-dose aspirin), Severe cardiovascular or neuromuscular comorbidities)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pain by NPRS and PPTs 2. Disc Morphology by disc height, disc echogenicity, and disc displacement (assessed via MSK-USG) 3. Neurological Recovery by SLR, NCS, and EMGTimepoint: Baseline, 1 month, 3 months, and 6 months post-intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Disability by Oswestry Disability Index (ODI)Timepoint: Baseline, 1 month, 3 months, and 6 months post-intervention | — |
Countries
Bangladesh
Contacts
Public ContactDr Kazi Md Amran Hossain
Jashore University of Science and Technology
Outcome results
None listed