Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: dd: dd
Intervention2: Neostigmine with sugammadex: Sugammadex 1 mg/kg followed by Neostigmine 50 mcg/kg with glycopyrrolate 10 mcg/kg will be administered when TOF count is two or more.
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
Eligibility
Inclusion criteria
Inclusion criteria: ASA physical status 1 and 2, between 18-65 years scheduled to undergo laparoscopic surgery.
Exclusion criteria
Exclusion criteria: 1.Allergy to study drugs 2.BMI more than 30 3.Serum creatinine more than 2.0 mg per dL 4.Patients taking hormonal birth control pills. 5.Breastfeeding mothers 6.Patients with anticipated difficult airway 7.Patients with suspected or known to have neuromuscular disorders. 8.H/o malignant hyperthermia Patients receiving medication at a dose or time known to interfere with NMBAs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To estimate and compare the time to reach TOF ratio more than 0.9 by using (neostigmine + sugammadex) vs (neostigmine) by objective parameters such as TOFR.Timepoint: Endoperative period | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate and compare time to spontaneous breathingTimepoint: Endoperative period;To estimate and compare time to extubationTimepoint: Endoperative period;To estimate and compare incidence of RNMB in both groups using TOF and diaphragm ultrasound - Diaphragm excursion using M mode at rest and deep breathingTimepoint: Baseline, TOF more than 0.9, 30 min after shifting to PACU. | — |
Countries
India
Contacts
Public ContactDr Chitra Rajeswari T
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
Outcome results
None listed