Health Condition 1: I52- Other heart disorders in diseasesclassified elsewhere
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
AIIMS Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients (18 years-80 years) scheduled for elective or emergency cardiac surgery with CPB, including coronary artery bypass grafting (CABG), valve replacements, or aortic aneurysm repair. 2. Availability of preoperative and postoperative laboratory data
Exclusion criteria
Exclusion criteria: 1.Patients with preexisting severe liver disease (e.g., cirrhosis, chronic hepatitis). 2.Active hematological disorders or malignancy. 3.Recent blood transfusions (within 1 month before surgery). 4.Incomplete perioperative data or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the association between preoperative red cell distribution width (RDW) levels and the incidence of liver injury in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)Timepoint: Preoperative period and everyday of postoperative period for 5 days or until discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess postoperative changes in RDW levels and their correlation with the severity of liver injuryTimepoint: Everyday of postoperative period for 5 days or until discharge;To examine the relationship between RDW and systemic inflammation, oxidative stress, and nutritional deficiencies (e.g., iron, folate, and vitamin B12)Timepoint: Everyday of postoperative period for 5 days or until discharge;To analyze the impact of intraoperative variables, such as cardiopulmonary bypass duration, aortic cross-clamp time, and intraoperative blood loss, on RDW and liver injury outcomesTimepoint: Everyday of postoperative period for 5 days or until discharge;To investigate the prognostic value of RDW in predicting the following outcomes: all-cause in-hospital mortality, length of ICU and hospital stay, incidence of postoperative complications, including acute kidney injury, sepsis, and prolonged mechanical ventilationTimepoint: Everyday of postoperative period for 5 days or until discharge;To explore the effect of preoperative blood transfusions on RDW levels and their potential influence on postoperative liver injury and other complicationsTimepoint: Everyday of postoperative period for 5 days or until discharge;To determine the utility of RDW as a cost-effective biomarker for early risk stratification and prognosis in cardiac surgery patientsTimepoint: Everyday of postoperative period for 5 days or until discharge | — |
Countries
India
Contacts
Public ContactDr Prasanta Kumar Das
All India Institute of Medical Sciences, Bhubaneswar
Outcome results
None listed