To observe the effects of two types of bone graft materials covered with amniotic membrane for the management of periodontal intrabony defects.

A clinical and radiographic evaluation of eggshell hydroxyapatite with amniotic membrane versus bovine bone-derived xenograft with amniotic membrane in human periodontal intrabony defects A randomized controlled clinical trial - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090109

Enrollment

Registered

2025-07-03

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system

Interventions

Intervention1: Intervention eggshell hydroxyapatite Comparator agent bovine bone xenograft : Intervention eggshell hydroxyapatite (0.5cc) Comparator agent Geistlich bovine bone xenograft (1 cc

Eligibility

Inclusion criteria

Inclusion criteria: 1.1.Patients between 25 to 55 years of age (Vani et.al., 2023) 2.Stage III or IV Periodontitis (2017 classification) 3 Probing depth (PD) greater than or equal to 6 mm 4.2 or 3 wall defects 5.Systemically healthy subjects 6.Subjects who have not received any periodontal treatment in the past six months 7.Subjects who have been informed about the study and has given consent.

Exclusion criteria

Exclusion criteria: 1. Teeth with pulpal/periapical involvement 2. Teeth with poor prognosis 3. Smokers and alcoholics 4. Pregnant/lactating women 5. Patients with known systemic diseases/conditions 6. Subjects unwilling to participate in the study.

Design outcomes

Primary

Measure	Time frame
The primary outcome measures will be to evaluate the clinical parameters such as Probing pocket depth, Plaque index, Gingival index, Gingival Bleeding Index and Relative attachment level and radiographic changes in bone fill and density in patients with intrabony defects following treatment with eggshell-derived hydroxyapatite with amniotic membrane and bovine bone-derived xenograft with amniotic membrane in periodontal intrabony defects.Timepoint: At 3 months and 6 months, patient will be recalled and assessed	—

Measure

Time frame

The primary outcome measures will be to evaluate the clinical parameters such as Probing pocket depth, Plaque index, Gingival index, Gingival Bleeding Index and Relative attachment level and radiographic changes in bone fill and density in patients with intrabony defects following treatment with eggshell-derived hydroxyapatite with amniotic membrane and bovine bone-derived xenograft with amniotic membrane in periodontal intrabony defects.Timepoint: At 3 months and 6 months, patient will be recalled and assessed

—

Secondary

Measure	Time frame
The secondary outcome will be patient comfort, improved oral hygiene status assessed using Plaque index, Gingival index, Gingival Bleeding Index , reduced mobility, increased clinical attachment level.Timepoint: At 3 months & 6 months, patient will be recalled & assessed	—

Countries

India

Contacts

Public ContactSmrithi K

Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore

Bhavyashetty123@gmail.com9880262593

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026