CHANGES IN THE PROPERTIES OF THE BLOOD VESSELS OF THE BRAIN CAUSED BY INHALATIONAL ANAESTHETIC AGENTS AND INFLUENCE OF THESE CHANGES ON BRAIN CONDIITONS DURING THE SURGERY IN PATIENTS UNDERGOING SURGICAL REMOVAL OF BRAIN TUMOR GLIOMA

Changes in cerebral vasodilation induced by sevoflurane, isoflurane, desflurane and the influence of these changes on intraoperative brain conditions in patients undergoing resection of gliomas under general anaesthesia- A Randomised Controlled Trial. - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/090036

Enrollment

126

Registered

2025-07-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: TRANSCRANIAL DOPPLER AND SUBDURAL PRESSURE MONITORING: THE CHANGES IN THE TCD PARAMETERS WITH RESPECT TO MCA FLOW VELOCITIES AMONGST 1.O MAC CONCENTRATION OF THREE COLATILE AGENTS WILL

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with Supratentorial Lesion glioma only. 2.Age group 18 to 60 years. 3.ASA physical grade I and II.

Exclusion criteria

Exclusion criteria: 1.Patients with poor acoustic temporal window. 2.Hemodynamically unstable patient requiring inotropic infusion. 3.Plaques or Stenosis observed on Carotid Artery Doppler in the preoperative period. 4.Midline shift of more than 5mm. 5.Refusal of Consent.

Design outcomes

Primary

Measure	Time frame
To correlate changes in Transcranial doppler parameters with 1 MAC concentration of sevoflurane, isoflurane and desflurane with: A) intraoperative brain relaxation score (subjective) B) Sub dural pressure measurement (objective)Timepoint: the primary outcome will be measured with a baseline transcranial doppler parameters prior to induction of anaesthesia, fifteen minutes post induction of anaesthesia and subdural pressure will be monitored post craniotomy.	—

Measure

Time frame

To correlate changes in Transcranial doppler parameters with 1 MAC concentration of sevoflurane, isoflurane and desflurane with: A) intraoperative brain relaxation score (subjective) B) Sub dural pressure measurement (objective)Timepoint: the primary outcome will be measured with a baseline transcranial doppler parameters prior to induction of anaesthesia, fifteen minutes post induction of anaesthesia and subdural pressure will be monitored post craniotomy.

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Secondary

Measure	Time frame
To compare the effect of all three inhalational agents on 1.hemoglobin mass loss in the intra-operative period. 2.The compare the effect of all three inhalational agents on emergence delirium and post operative deliriumTimepoint: The intraoperative blood loss is calculated by the haemoglobin mass loss formula which considers the following three parameters: 1.Patientâ??s pre-operative hemoglobin analysed by HemoCue 2.Patientâ??s post-operative hemoglobin analysed by HemoCue 3.Patientsâ??s estimated blood volume. Patientâ??s postoperative hemoglobin will be measured in the immediate postoperative period (0 hrs), 12 hrs and 24hrs postoperatively and the lowest among the three values will be considered. This will be assessed using confusion assessment score for three post operative days	—

Measure

Time frame

To compare the effect of all three inhalational agents on 1.hemoglobin mass loss in the intra-operative period. 2.The compare the effect of all three inhalational agents on emergence delirium and post operative deliriumTimepoint: The intraoperative blood loss is calculated by the haemoglobin mass loss formula which considers the following three parameters: 1.Patientâ??s pre-operative hemoglobin analysed by HemoCue 2.Patientâ??s post-operative hemoglobin analysed by HemoCue 3.Patientsâ??s estimated blood volume. Patientâ??s postoperative hemoglobin will be measured in the immediate postoperative period (0 hrs), 12 hrs and 24hrs postoperatively and the lowest among the three values will be considered. This will be assessed using confusion assessment score for three post operative days

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Countries

India

Contacts

Public ContactDr SUDHIR V

NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES

vsudhir77@gmail.com9900793108

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026