Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery
Conditions
Interventions
Intervention1: Group HPI: Patients in HPI group will be monitored with EV 1000 HPI monitor (Edwards Lifescience) and management will be done as per study protocol. Firstly, baseline variables as provi
Sponsors
Postgraduate Institute of Medical Education and research, Chandigarh ( INDIA)
Eligibility
Inclusion criteria
Inclusion criteria: Presenting for craniotomy under general anaesthesia for intracranial lesions. AS I and II Age above than 18 years Written informed consent
Exclusion criteria
Exclusion criteria: Refusal of consent Surgery without controlled ventilation/monitored anaesthesia care Contraindication to invasive blood pressure monitoring Atrial fibrillation Pregnancy Massive Ascites GCS less than 15 Known pulmonary disease (Asthma, COPD, interstitial lung disease, current smoker) Known intracardiac shunts and severe valvular heart disease. Patient with ongoing active infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time weighted average mean arterial pressure (MAP) less than 65 mmHg (TWA-AUT-65) in both the groupsTimepoint: On the day of operation | — |
Secondary
| Measure | Time frame |
|---|---|
| Time weighted average MAP less than 60 mm Hg (TWA-AUT-60)Timepoint: On the day of operation;Time weighted average MAP less than 55 mm Hg (TWA-AUT-55)Timepoint: On the day of operation;Time weighted average MAP less than 50 mm Hg (TWA-AUT-50)Timepoint: On the day of operation;Serum creatinineTimepoint: After 24 hours, 48 hours, and 72 hours;Hospital stayTimepoint: At the end of the day;Intensive Care Unit stayTimepoint: At the end of the day;Perioperative fluid intake and blood lossTimepoint: On the day of operation;Concentration of serum troponinTimepoint: at baseline, and day 1 postoperative;Vasopressors and inotropic medication usedTimepoint: From day of operation till end of 7 days;SurvivalTimepoint: at day 90 after surgery;GOSETimepoint: at discharge, 3 months, and 1 year;Number of events of hypotension (MAP less than 65 mm Hg)Timepoint: On the day of operation;Predictive value of HPI in predicting MAP less than 65 mmHg in the control groupTimepoint: On the day of operation | — |
Countries
India
Contacts
Public ContactDr Shiv Lal Soni
Postgraduate Institute of Medical Education and research, Chandigarh ( INDIA)
Outcome results
None listed