Nasal Lignocaine Spray for Relief of Post-Dural Puncture Headache in Obstetric Patients: A Randomized Controlled Trial

COMPARING THE EFFICACY OF SPHENOPALATINE GANGLION BLOCK FOR TREATMENT OF POSTDURAL PUNCTURE HEADACHE USING 2 percent LIGNOCAINE SPRAY NASALLY AMONG OBSTETRIC POPULATION: RANDOMIZED CONTROLLED TRIAL. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/089968

Enrollment

Registered

2025-07-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G440- Cluster headaches and other trigeminal autonomic cephalgias (TAC)

Interventions

Intervention1: Sphenopalatine Ganglion Block (SPGB): The SPGB will be performed using a transnasal approach. A cotton- tipped applicator soaked in local anesthetic (e.g., 2% lidocaine) will be inserte

Eligibility

Inclusion criteria

Inclusion criteria: Obstetric patients experiencing PDPH following spinal anesthesia. Young patients (aged 18-40) experiencing PDPH following lumbar puncture after spinal anesthesia. Patients who provide informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: Patients with contraindications to SPGB, such as severe nasal septum deviation or active nasal infection. Patients with a history of allergy to local anesthetics. Patients with significant comorbid conditions that may interfere with study outcomes. Patients who decline to participate or withdraw consent during the study

Design outcomes

Primary

Measure	Time frame
Pain relief, measured using a visual analog scale (VAS) for headache intensity at multiple time points: baseline, 30 minutes, 1 hour, 6 hours, 12 hours, 24 hours, and 48 hours post-intervention.Timepoint: Pain relief, measured using a visual analog scale (VAS) for headache intensity at multiple time points: baseline, 30 minutes, 1 hour, 6 hours, 12 hours, 24 hours, and 48 hours post-intervention.	—

Secondary

Measure	Time frame
Evaluate the Efficiency of SPGB in Terms of Time to Relief Determine the average time taken for SPGB to provide pain relief compared to other treatments. Analyze the duration of pain relief provided by SPGB. Examine Patient Outcomes Satisfaction Assess patient-reported outcomes including pain scores, quality of life, overall satisfaction with SPGB treatment.Timepoint: Pain relief, measured using a visual analog scale (VAS) for headache intensity at multiple time points baseline, 30 minutes, 1 hour, 6 hours, 12 hours, 24 hours, 48 hours post intervention.	—

Measure

Time frame

Evaluate the Efficiency of SPGB in Terms of Time to Relief Determine the average time taken for SPGB to provide pain relief compared to other treatments. Analyze the duration of pain relief provided by SPGB. Examine Patient Outcomes Satisfaction Assess patient-reported outcomes including pain scores, quality of life, overall satisfaction with SPGB treatment.Timepoint: Pain relief, measured using a visual analog scale (VAS) for headache intensity at multiple time points baseline, 30 minutes, 1 hour, 6 hours, 12 hours, 24 hours, 48 hours post intervention.

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Countries

India

Contacts

Public ContactDr Rohit Parashar

Dr. S.N Medical college, Jodhpur

neelamneki1997@gmail.com8302537601

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026