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A study comparing the effects of Dexmedetomidine vs Magnesium Sulphate nebulisation in reducing sore throat in patients undergoing general anaesthesia

Comparison of nebulized Dexmedetomidine vs Magnesium Sulphate for the attenuation of postoperative sore throat in patients undergoing general anaesthesia - Nil

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/089940
Enrollment
206
Registered
2025-07-01
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Preoperative Nebulisation with study drugs for prevention of post operative sore throat: Preoperative Nebulisation with Dexmedetomidine or Magnesium Sulphate for prevention of postopera

Sponsors

Dr Ashley Eapen
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA-PS I-II 2. Posted for elective surgical procedures in supine position under general anaesthesia with endotracheal intubation 3.Duration of surgery : 2-5 hours

Exclusion criteria

Exclusion criteria: 1. Patients who refuse or lack the capacity to give consent 2. History of preoperative sore throat, respiratory tract infection, chronic lung diseases 3. Known allergy to the study drug 4. Pregnancy 5. Anticipated difficult airway 6. BMI greater than 30 kg/m2 7. Patients undergoing oral, nasal, head and neck surgeries 8. Requiring more than one attempt at intubation

Design outcomes

Primary

MeasureTime frame
To compare the incidence of the sore throat, hoarseness of voice and cough in the postoperative period in patients prophylactically treated with Dexmedetomidine or Magnesium Sulphate undergoing elective surgeries under general anaesthesia with tracheal intubationTimepoint: Postoperatively at 0, 2, 4 and 6 hours from the time of extubation

Secondary

MeasureTime frame
To compare the effects of nebulization of the study drugs on respiratory rate and hemodynamic parameters such as heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressureTimepoint: Postoperatively at 0, 2, 4 and 6 hours from the time of extubation

Countries

India

Contacts

Public ContactDr Litha Mary Mathew

Believers Church Medical College Hospital

lthmathew@gmail.com9447349649

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026