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An observational study to examine and compare effects of four medications given before Propofol injection is Cold saline Lignocaine Cold saline plus Lignocaine and Normal saline for reducing pain during Propofol injection in patients undergoing general anaesthesia

Comparative analysis of pain on Propofol injection with pretreatment using Cold saline Lignocaine Cold saline plus Lignocaine and Normal saline in patients undergoing general anaesthesia A Prospective Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/089936
Enrollment
132
Registered
2025-07-01
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Cold Normal Saline (at 4 degree Celsius): Dose: 5ml Route of administration: intravenous injection over 5 seconds Frequency: Single Dose Intervention2: Lignocaine Hydrochloride injecti

Sponsors

Hrithika
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.The patient who are undergoing general anaesthesia and eligible cases during the study period are covered 2.American Society of Anaesthesiologist physical status (ASA PS) I and II 3.BMI 18-24 Kg/m2

Exclusion criteria

Exclusion criteria: 1.Allergy to study medication 2.Serious venous insufficiency 3.Pregnant/lactating women

Design outcomes

Primary

MeasureTime frame
Incidence and severity of pain on propofol injection in patients pretreated with cold saline, lignocaine, cold saline + lignocaine and normal saline using pain scoreTimepoint: pain score is taken Immediately after giving 5ml of propofol injection (within 5 to 10 seconds)—

Secondary

MeasureTime frame
Post operative recall of pain on propofol injection in patients pretreated with cold saline, lignocaine, cold saline + lignocaine and normal salineTimepoint: post-operatively patient will grade pain using numerical rating scale when fully conscious within 1-2 hours—

Countries

India

Contacts

Public ContactDr Swathi Kumari K

Yenepoya Medical College and Hospital

hithabhandary@gmail.com7338555009

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026